Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | PYGL | P06737 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735538 | 1.00 | PLK1 (0.57) | PLK1MMP3HDAC8EGLN1ALDH1A1 | |
| SCHEMBL25386182 | 1.00 | PLK1 (0.57) | PLK1MMP3HDAC8EGLN1ALDH1A1 | |
| SCHEMBL9828116 | 0.90 | PLK1 (0.50) | PLK1MMP3HDAC8EGLN1ALDH1A1 | |
| SCHEMBL9828124 | 0.90 | PLK1 (0.50) | PLK1MMP3HDAC8EGLN1ALDH1A1 | |
| SCHEMBL7031326 | 0.90 | PLK1 (0.55) | PLK1MMP3HDAC8ALDH1A1LMNA | |
| SCHEMBL14316524 | 0.88 | PLK1 (0.50) | PLK1MMP3HDAC8EGLN1ALDH1A1 | |
| SCHEMBL10655055 | 0.86 | PYGL (0.53) | PLK1MMP3HDAC8ALDH1A1LMNA | |
| SCHEMBL10655061 | 0.86 | PYGL (0.53) | PLK1MMP3HDAC8ALDH1A1LMNA | |
| SCHEMBL9829673 | 0.85 | GPR139 (0.49) | PLK1MMP3HDAC8EGLN1ALDH1A1 | |
| SCHEMBL9829668 | 0.85 | GPR139 (0.49) | PLK1MMP3HDAC8EGLN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023172880-A2 | PCNA INHIBITORS AND USES THEREOF | CITY OF HOPE (US) | 2023-09-14 | — | — | WO | disclosed |