Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.45 |
| ▸ | PYGL | P06737 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828116 | 1.00 | PLK1 (0.50) | PLK1CTSBMMP3HDAC8ALDH1A1 | |
| SCHEMBL25388151 | 0.90 | PLK1 (0.57) | PLK1MMP3HDAC8ALDH1A1LMNA | |
| SCHEMBL735538 | 0.90 | PLK1 (0.57) | PLK1MMP3HDAC8ALDH1A1LMNA | |
| SCHEMBL25386182 | 0.90 | PLK1 (0.57) | PLK1MMP3HDAC8ALDH1A1LMNA | |
| SCHEMBL9830965 | 0.87 | CTSB (0.48) | PLK1CTSBMMP3HDAC8ALDH1A1 | |
| SCHEMBL9830972 | 0.87 | CTSB (0.48) | PLK1CTSBMMP3HDAC8ALDH1A1 | |
| SCHEMBL9831137 | 0.84 | PLK1 (0.60) | PLK1MMP3HDAC8ALDH1A1LMNA | |
| SCHEMBL2405015 | 0.84 | PLK1 (0.60) | PLK1MMP3HDAC8ALDH1A1LMNA | |
| SCHEMBL14316524 | 0.84 | PLK1 (0.50) | PLK1CTSBMMP3HDAC8ALDH1A1 | |
| SCHEMBL7031326 | 0.81 | PLK1 (0.55) | PLK1MMP3HDAC8ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |