SCHEMBL25399767

SCHEMBL25399767

CC(C)(C)[Si](C)(C)O[C@H]1[C@H](F)[C@H](n2ccc(=O)[nH]c2=O)O[C@@H]1CO

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC28A1 O00337 1/20 0.54
SLC28A2 O43868 1/20 0.54
SLC29A1 Q99808 1/20 0.54
SLC28A3 Q9HAS3 1/20 0.54
DUT P33316 1/20 0.47
P2RY14 Q15391 7/20 0.45
P2RY2 P41231 6/20 0.43
P2RY6 Q15077 5/20 0.43
P2RY4 P51582 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19536299 1.00 SLC28A1 (0.54) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL19590162 1.00 SLC28A1 (0.54) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL16906839 1.00 SLC28A1 (0.54) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL21566394 1.00 SLC28A1 (0.54) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL23880692 1.00 SLC28A1 (0.54) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL18049486 1.00 SLC28A1 (0.54) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL23710676 0.90 SLC28A1 (0.57) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL8642265 0.90 SLC28A1 (0.57) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL24487716 0.89 DUT (0.56) SLC28A1SLC28A2SLC29A1SLC28A3DUT
SCHEMBL25399050 0.89 DUT (0.56) SLC28A1SLC28A2SLC29A1SLC28A3DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250145654-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE ROME THERAPEUTICS, INC. 2025-05-08 US disclosed
EP-4493573-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE Rome Therapeutics, Inc. (US) 2025-01-22 EP disclosed
US-12187758-B2 Compounds and methods for treating disease ROME THERAPEUTICS, INC. (US) 2025-01-07 US disclosed
WO-2024103016-A1 4'-HALOMETHYL-CYTIDINE PHOSPHORAMIDATES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS ROME THERAPEUTICS, INC. (US) 2024-05-16 WO disclosed
US-20230374058-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE ROME THERAPEUTICS, INC. 2023-11-23 US disclosed
WO-2023178133-A9 COMPOUNDS AND METHODS FOR TREATING DISEASE ROME THERAPEUTICS, INC. (US) 2023-10-26 WO disclosed
US-20230295212-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE ROME THERAPEUTICS INC (US) 2023-09-21 US disclosed
WO-2023178133-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE ROME THERAPEUTICS, INC. (US) 2023-09-21 WO disclosed
CN-114288313-B Application of pyrimidine nucleoside medicine in preparing medicine for preventing or treating coronavirus infectious diseases 常晓宇 2023-07-04 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230295212-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE EHMT1, POLRMT, RNASE1 SLC28A1 159/4885SLC28A2 603/4885SLC29A1 254/4885
US-20230374058-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE EHMT1, POLRMT, RNASE1 SLC28A1 159/4885SLC28A2 603/4885SLC29A1 254/4885
US-20250145654-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE EHMT1, POLRMT, RNASE1 SLC28A1 159/4885SLC28A2 603/4885SLC29A1 254/4885
US-12187758-B2 Compounds and methods for treating disease EHMT1, POLRMT, RNASE1 SLC28A1 159/4885SLC28A2 603/4885SLC29A1 254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.