Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801033 | 0.93 | CA12 (0.67) | HDAC1HDAC8NR1I2CA12CA9 | |
| SCHEMBL812702 | 0.83 | CA12 (0.78) | NR1I2CA12CA9NR1H2NR1H3 | |
| SCHEMBL11910521 | 0.80 | CA12 (0.86) | NR1I2CA12CA9NR1H2NR1H3 | |
| SCHEMBL10186890 | 0.79 | FFAR1 (0.74) | HDAC1HDAC8NR1I2CA12CA9 | |
| SCHEMBL6301401 | 0.79 | NPC1 (0.67) | HDAC1HDAC8NR1I2CA12CA9 | |
| SCHEMBL3997987 | 0.79 | NR1I2 (0.61) | HDAC1HDAC8NR1I2CA12CA9 | |
| SCHEMBL10186889 | 0.79 | PGR (0.74) | NR1I2CA12CA9NR1H2NR1H3 | |
| SCHEMBL2690068 | 0.79 | NR1I2 (0.61) | HDAC1HDAC8NR1I2CA12CA9 | |
| SCHEMBL5020683 | 0.76 | HDAC1 (1.00) | HDAC1HDAC8NR1I2MAPTMEN1 | |
| SCHEMBL10186886 | 0.76 | L3MBTL1 (0.83) | NR1I2CA12CA9NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250188078-A1 | SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE | CORNELL UNIVERSITY (US) | 2025-06-12 | — | — | US | disclosed |
| EP-4490160-A2 | SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE | Cornell University (US) | 2025-01-15 | — | — | EP | disclosed |
| WO-2023173136-A2 | SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE | CORNELL UNIVERSITY (US) | 2023-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250188078-A1 | SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE | DDB1, CUL4A, CUL4B | HDAC1 912/4885HDAC8 1341/4885NR1I2 617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.