Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | FPR2 | P25090 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EED | O75530 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25215406 | 0.83 | CYP3A4 (0.48) | KDM4EFPR2CYP3A4CYP2D6OPRK1 | |
| SCHEMBL17824294 | 0.77 | CYP3A4 (0.49) | KDM4ERAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL22234295 | 0.77 | ESR1 (0.57) | KDM4EFPR2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23461135 | 0.74 | F2 (0.48) | KDM4EFPR2KMT2AMEN1ALDH1A1 | |
| SCHEMBL18839661 | 0.73 | L3MBTL1 (0.45) | KDM4ERAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20068591 | 0.73 | FPR2 (0.47) | KDM4EFPR2RAB9AKMT2AMEN1 | |
| SCHEMBL27967584 | 0.73 | TMIGD3 (0.65) | RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL368204 | 0.72 | POLB (0.51) | KDM4EFPR2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL16607262 | 0.72 | LMNA (0.52) | KDM4ERAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL29156333 | 0.72 | NPC1 (0.42) | PPIDKDM4EFPR2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023096850-A1 | PHOSPHOINOSITIDE 3 KINASE GAMMA INHIBITORS AND COMPOSITIONS AND METHODS THEREOF | GEODE THERAPEUTICS INC. (US) | 2023-06-01 | — | — | WO | disclosed |
| WO-2023096850-A1 | PHOSPHOINOSITIDE 3 KINASE GAMMA INHIBITORS AND COMPOSITIONS AND METHODS THEREOF | GEODE THERAPEUTICS INC. (US) | 2023-06-01 | — | — | WO | disclosed |