SCHEMBL25423917

SCHEMBL25423917

COc1c(F)ccc2[nH]cc(CCN)c12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 9/20 0.58
HTR1A P08908 6/20 0.51
HTR1D P28221 4/20 0.51
TRPM8 Q7Z2W7 3/20 0.51
HTR2C P28335 3/20 0.51
HTR1B P28222 2/20 0.51
CYP1A2 P05177 1/20 0.51
MAPT P10636 1/20 0.51
TSHR P16473 1/20 0.51
NFKB1 P19838 1/20 0.51
HTR7 P34969 1/20 0.51
HTR6 P50406 1/20 0.51
HTR4 Q13639 1/20 0.51
BLM P54132 1/20 0.50
PMP22 Q01453 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
MPO P05164 1/20 0.48
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
GPR84 Q9NQS5 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31077741 1.00 HTR2A (0.58) HTR2AHTR1AHTR1DTRPM8HTR2C
SCHEMBL26451594 0.86 HTR2A (0.60) HTR2AHTR1AHTR1DTRPM8HTR2C
SCHEMBL25748455 0.85 HTR2A (0.53) HTR2AHTR1AHTR1DHTR2CHTR1B
SCHEMBL31440963 0.85 HTR2A (0.53) HTR2AHTR1AHTR1DHTR2CHTR1B
SCHEMBL3210741 0.85 HTR2A (0.67) HTR2AHTR1AHTR1DTRPM8HTR2C
SCHEMBL25434919 0.84 HTR1A (0.67) HTR2AHTR1AHTR1DHTR2CHTR1B
SCHEMBL30483758 0.84 HTR1A (0.67) HTR2AHTR1AHTR1DHTR2CHTR1B
SCHEMBL25427868 0.82 HTR1A (0.54) HTR2AHTR1AHTR1DHTR2CHTR1B
SCHEMBL25421988 0.81 PARP1 (0.48) HTR2AHTR1AHTR2CHTR6MPO
SCHEMBL30483759 0.81 PARP1 (0.48) HTR2AHTR1AHTR2CHTR6MPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250101038-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-03-27 US disclosed
WO-2023115166-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 WO disclosed
WO-2023115166-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250101038-A1 COMPOUNDS NLN, SLC18A2, PYGB HTR2A 94/4885HTR1A 185/4885HTR1D 344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.