Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.67 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | HTR1D | P28221 | 3/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9666180 | 0.88 | HTR2A (0.50) | HTR2AHTR1AHTR2CHTR1DHTR6 | |
| SCHEMBL26451594 | 0.86 | HTR2A (0.60) | HTR2AHTR1AHTR2CHTR1DHTR6 | |
| SCHEMBL25423917 | 0.85 | HTR2A (0.58) | HTR2AHTR1AHTR2CHTR1DHTR6 | |
| SCHEMBL1971484 | 0.85 | HTR2A (0.67) | HTR2AHTR1AHTR2CHTR1DHTR6 | |
| SCHEMBL31077741 | 0.85 | HTR2A (0.58) | HTR2AHTR1AHTR2CHTR1DHTR6 | |
| SCHEMBL2541508 | 0.84 | HTR2A (0.65) | HTR2AHTR1AHTR2CHTR1DHTR6 | |
| SCHEMBL34433458 | 0.82 | HTR1A (0.73) | HTR2AHTR1AHTR2CHTR1DHTR6 | |
| SCHEMBL23791403 | 0.82 | HTR1A (0.73) | HTR2AHTR1AHTR2CHTR1DHTR6 | |
| SCHEMBL9665786 | 0.82 | MTNR1A (0.62) | HTR2AHTR1AHTR2CHTR1DHTR6 | |
| SCHEMBL30888860 | 0.82 | MTNR1A (0.62) | HTR2AHTR1AHTR2CHTR1DHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063125-A1 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | UNIVERSITY OF SUNDERLAND (GB) | 2010-03-11 | — | — | US | claimed |
| US-8258173-B2 | Melatonin derivatives and their use as antioxidants | UNIVERSITY OF SUNDERLAND (GB) | 2012-09-04 | — | — | US | disclosed |
| US-20100063125-A1 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | UNIVERSITY OF SUNDERLAND (GB) | 2010-03-11 | — | — | US | disclosed |
| EP-2083818-A2 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | University of Sunderland (GB) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008062167-A2 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | UNIVERSITY OF SUNDERLAND (GB) | 2008-05-29 | — | — | WO | disclosed |
| EP-0240352-B1 | 5-FLUOROURACIL DERIVATIVES AND PROCESSES FOR PRODUCING THEREOF | Chisso Corporation (JP) | 1992-12-16 | — | — | EP | disclosed |
| US-4792607-A | ANTICANCER MEDICINE INTERRMEDIATES | CHISSO CORPORATION (JP) | 1988-12-20 | — | — | US | disclosed |
| EP-0240352-A2 | 5-Fluorouracil derivatives and processes for producing thereof | Chisso Corporation (JP) | 1987-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063125-A1 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | MTNR1A, MTNR1B, TXNRD2 | HTR2A 414/4885HTR1A 275/4885HTR2C 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.