Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25422890 | 0.88 | MAPT (0.41) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL31038311 | 0.88 | CA12 (0.44) | ALDH1A1KDM4ECA12CA1CA2 | |
| SCHEMBL28328775 | 0.77 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EPTGS1PTGS2 | |
| SCHEMBL8380196 | 0.75 | PDE4B (0.43) | HPGDKDM4ECA12CA1CA2 | |
| SCHEMBL15924317 | 0.75 | CA12 (0.43) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL3343670 | 0.73 | CA1 (0.47) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL30745155 | 0.73 | MGLL (0.50) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL5323825 | 0.73 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4EPTGS1PTGS2 | |
| SCHEMBL29151112 | 0.73 | MGLL (0.50) | ALDH1A1HPGDKDM4ECA12CA1 | |
| SCHEMBL5806043 | 0.70 | CYP11B1 (0.52) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250100960-A1 | NAPHTHALENE AND QUINOLINE ANALOGS AS RXFP1 AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2025-03-27 | — | — | US | disclosed |
| EP-4448504-A1 | NAPHTHALENE AND QUINOLINE ANALOGS AS RXFP1 AGONISTS | Bristol-Myers Squibb Company (US) | 2024-10-23 | — | — | EP | disclosed |
| CN-118414330-A | Naphthalene and quinoline analogs as RXFP1 agonists | 百时美施贵宝公司 | 2024-07-30 | — | — | CN | disclosed |
| WO-2023114818-A1 | NAPHTHALENE AND QUINOLINE ANALOGS AS RXFP1 AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250100960-A1 | NAPHTHALENE AND QUINOLINE ANALOGS AS RXFP1 AGONISTS | RXFP1, RXFP2, RXFP3 | ALDH1A1 1269/4885HPGD 316/4885KDM4E 4320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.