SCHEMBL25424905

SCHEMBL25424905

COc1cc2c(C(=O)C(=O)N(C(C)C)C(C)C)c[nH]c2cc1C

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ PRKAB2 O43741 2/20 0.37
▸ PRKAG1 P54619 2/20 0.37
▸ PRKAA2 P54646 2/20 0.37
▸ PRKAA1 Q13131 2/20 0.37
▸ PRKAG3 Q9UGI9 2/20 0.37
▸ PRKAG2 Q9UGJ0 2/20 0.37
▸ PRKAB1 Q9Y478 2/20 0.37
▸ NR4A2 P43354 3/20 0.36
▸ TUBB1 Q9H4B7 1/20 0.36
▸ MTNR1A P48039 1/20 0.36
▸ MTNR1B P49286 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25747919 0.89 MAPK14 (0.38) MAPK14KDM4EMAPK1PRKAB2PRKAG1
SCHEMBL25438668 0.86 ALDH1A1 (0.38) MAPK14KDM4EMAPK1MTNR1AMTNR1B
SCHEMBL31077755 0.86 MAPK14 (0.47) MAPK14KDM4EMAPK1PRKAB2PRKAG1
SCHEMBL25747875 0.86 MAPK14 (0.47) MAPK14KDM4EMAPK1PRKAB2PRKAG1
SCHEMBL25747925 0.82 ALDH1A1 (0.41) MAPK14KDM4EMAPK1PRKAB2PRKAG1
SCHEMBL25424702 0.81 ALDH1A1 (0.40) MAPK14KDM4EMAPK1PRKAB2PRKAG1
SCHEMBL25747942 0.81 KDM4E (0.39) MAPK14KDM4EMAPK1MTNR1AMTNR1B
SCHEMBL31077720 0.81 KDM4E (0.39) MAPK14KDM4EMAPK1MTNR1AMTNR1B
SCHEMBL25241421 0.80 PRKAB2 (0.43) KDM4EMAPK1PRKAB2PRKAG1PRKAA2
SCHEMBL31077782 0.80 PRKAB2 (0.43) KDM4EMAPK1PRKAB2PRKAG1PRKAA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250101038-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-03-27 — — US disclosed
CN-118715204-A Compounds of formula (I) 普赛洛私人有限公司 2024-09-27 — — CN disclosed
WO-2023115166-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 — — WO disclosed
WO-2023115166-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250101038-A1 COMPOUNDS NLN, SLC18A2, PYGB MAPK14 2602/4885KDM4E 3243/4885MAPK1 3012/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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