Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25255599 | 0.91 | CYP11B1 (0.54) | CYP11B1CYP11B2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30245596 | 0.91 | CYP11B1 (0.54) | CYP11B1CYP11B2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5046565 | 0.79 | MAPT (0.46) | SMN1; SMN2KDM4EALDH1A1HTTMEN1 | |
| SCHEMBL25426943 | 0.79 | DGAT2 (0.63) | SMN1; SMN2KDM4EALDH1A1HTTHDAC1 | |
| SCHEMBL6389607 | 0.78 | CYP11B1 (0.71) | CYP11B1CYP11B2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30245843 | 0.78 | PDE5A (0.44) | CYP11B1CYP11B2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL29194699 | 0.77 | CYP11B1 (0.52) | CYP11B1CYP11B2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9416628 | 0.77 | KDM4E (0.79) | SMN1; SMN2KDM4EALDH1A1HTTHDAC1 | |
| SCHEMBL25427024 | 0.77 | CYP11B1 (0.46) | CYP11B1CYP11B2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL25427086 | 0.77 | CYP11B1 (0.46) | CYP11B1CYP11B2SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4384516-A1 | AMINOARYL-INTEGRIN AGONISTS COMPOUNDS | Texas Heart Institute (US) | 2024-06-19 | — | — | EP | disclosed |
| CN-117916237-A | Amino aryl integrin agonist compounds | 德克萨斯心脏研究所 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023018472-A9 | AMINOARYL-INTEGRIN AGONISTS COMPOUNDS | TEXAS HEART INSTITUTE (US) | 2023-07-13 | — | — | WO | disclosed |
| WO-2023018472-A1 | AMINOARYL-INTEGRIN AGONISTS COMPOUNDS | TEXAS HEART INSTITUTE (US) | 2023-02-16 | — | — | WO | disclosed |