SCHEMBL254265

SCHEMBL254265

C=CCSc1cccnc1-c1cccc(-c2ccccn2)n1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.49
SMN1; SMN2 Q16637 6/20 0.49
HTT P42858 5/20 0.49
LMNA P02545 4/20 0.49
L3MBTL1 Q9Y468 3/20 0.49
CCR1 P32246 3/20 0.49
CCR5 P51681 3/20 0.49
CCR8 P51685 3/20 0.49
TP53 P04637 2/20 0.49
ALOX15 P16050 2/20 0.49
TDP1 Q9NUW8 2/20 0.49
ALPL P05186 1/20 0.49
HSP90AA1 P07900 1/20 0.49
ALPI P09923 1/20 0.49
ALPG P10696 1/20 0.49
MAPK1 P28482 1/20 0.49
SLC2A1 P11166 1/20 0.39
HIF1A Q16665 2/20 0.38
CYP1A2 P05177 1/20 0.38
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9986851 0.85 KDM4E (0.44) KDM4ESMN1; SMN2HTTLMNAL3MBTL1
SCHEMBL27690425 0.77 L3MBTL1 (0.44) KDM4ESMN1; SMN2HTTLMNAL3MBTL1
SCHEMBL7932521 0.77 KDM4E (0.58) KDM4ESMN1; SMN2HTTLMNAL3MBTL1
SCHEMBL254657 0.76 KDM4E (0.53) KDM4ESMN1; SMN2HTTLMNAL3MBTL1
SCHEMBL9565644 0.74 CYP1A2 (0.33) SMN1; SMN2L3MBTL1CYP1A2ALDH1A1PKM
SCHEMBL253731 0.73 SLC2A1 (0.53) KDM4ESMN1; SMN2HTTLMNAL3MBTL1
SCHEMBL9565640 0.71 L3MBTL1 (0.36) SMN1; SMN2L3MBTL1CYP1A2HPGDALDH1A1
SCHEMBL9565639 0.70 L3MBTL1 (0.41) KDM4ESMN1; SMN2HTTLMNAL3MBTL1
SCHEMBL30172832 0.70 KDM4E (1.00) KDM4ESMN1; SMN2HTTLMNAL3MBTL1
SCHEMBL7964803 0.70 KDM4E (1.00) KDM4ESMN1; SMN2HTTLMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9891185-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2018-02-13 US disclosed
US-9662057-B2 Integrated sample acquisition and analyte measurement method ABBOTT DIABETES CARE INC. (US) 2017-05-30 US disclosed
US-20160334356-A1 Small Volume In Vitro Analyte Sensor THERASENSE, INC. 2016-11-17 US disclosed
US-20160235350-A1 Integrated Sample Acquisition and Analyte Measurement Device THERASENSE, INC. 2016-08-18 US disclosed
US-9341591-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-05-17 US disclosed
US-9316609-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-04-19 US disclosed
US-9291592-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-03-22 US disclosed
US-9271669-B2 Method for integrated sample acquisition and analyte measurement device ABBOTT DIABETES CARE INC. (US) 2016-03-01 US disclosed
US-9234863-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-01-12 US disclosed
US-20150245791-A1 Integrated Sample Acquisition and Analyte Measurement Device THERASENSE, INC. 2015-09-03 US disclosed
US-20040054267-A1 Small volume in vitro analyte sensor THERASENSE, INC. 2004-03-18 US disclosed
US-20030199744-A1 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator THERASENSE, INC. (US) 2003-10-23 US disclosed
US-6618934-B1 Method of manufacturing small volume in vitro analyte sensor THERASENSE, INC. 2003-09-16 US disclosed
US-6592745-B1 Analytical sensors for the detection of bioanalytes in a small volume sample; to monitor glucose in diabetic patients and lactate during critical care THERASENSE, INC. 2003-07-15 US disclosed
US-6591125-B1 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator THERASENSE, INC. 2003-07-08 US disclosed
US-6461496-B1 BLOOD GLUCOSE THERASENSE, INC. 2002-10-08 US disclosed
US-6338790-B1 DETECTION OF BIOANALYTES IN A SMALL VOLUME SAMPLE; CONCENTRATION OF A BIOMOLECULE, SUCH AS GLUCOSE OR LACTATE, USING TECHNIQUES SUCH AS COULOMETRY, AMPEROMETRY, AND POTENTIOMETRY. AN ENZYME CAPABLE OF CATALYZING THE THERASENSE, INC. 2002-01-15 US disclosed
US-6299757-B1 ANALYTICAL SENSORS FOR THE DETECTION OF BIOANALYTES; ESPECIALLY MONITORING GLUCOSE LEVELS IN DIABETIC PATIENTS THERASENSE, INC. 2001-10-09 US disclosed
EP-1119637-A1 SMALL VOLUME $i(IN VITRO) ANALYTE SENSOR WITH DIFFUSIBLE OR NON-LEACHABLE REDOX MEDIATOR Therasense, Inc. (US) 2001-08-01 EP disclosed
WO-2000020626-A1 SMALL VOLUME IN VITRO ANALYTE SENSOR WITH DIFFUSIBLE OR NON-LEACHABLE REDOX MEDIATOR THERASENSE, INC. (US) 2000-04-13 WO disclosed