⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25429970 | 0.86 | FFAR2 (0.32) | — | |
| SCHEMBL19941737 | 0.79 | PDE5A (0.36) | — | |
| SCHEMBL19941723 | 0.79 | PDE5A (0.36) | — | |
| SCHEMBL25433662 | 0.73 | HCAR2 (0.32) | — | |
| SCHEMBL26188540 | 0.69 | — | — | |
| SCHEMBL25430953 | 0.69 | CHEK1 (0.32) | — | |
| SCHEMBL20837156 | 0.68 | ARF6 (0.30) | — | |
| SCHEMBL20931266 | 0.63 | IDO1 (0.31) | — | |
| SCHEMBL21877671 | 0.63 | FFAR2 (0.34) | — | |
| SCHEMBL25430889 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250171405-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD (US) | 2025-05-29 | — | — | US | disclosed |
| EP-4482487-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | Biohaven Therapeutics Ltd. (US) | 2025-01-01 | — | — | EP | disclosed |
| WO-2023164538-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164538-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (US) | 2023-08-31 | — | — | WO | disclosed |