Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GALR2 | O43603 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | CCR6 | P51684 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2535876 | 0.88 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2LMNAGALR2MITF | |
| SCHEMBL28497946 | 0.85 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNAGALR2MITF | |
| SCHEMBL28499292 | 0.82 | LMNA (0.48) | ALDH1A1SMN1; SMN2LMNAGALR2MITF | |
| SCHEMBL9793657 | 0.79 | SMN1; SMN2 (0.67) | ALDH1A1SMN1; SMN2LMNAGALR2MITF | |
| SCHEMBL5951849 | 0.78 | KMT2A (0.53) | ALDH1A1SMN1; SMN2LMNAGALR2MITF | |
| SCHEMBL8178297 | 0.76 | AKR1C3 (0.50) | ALDH1A1SMN1; SMN2LMNAGALR2MITF | |
| SCHEMBL3266479 | 0.76 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2LMNAGALR2MITF | |
| SCHEMBL3266352 | 0.75 | LMNA (0.55) | ALDH1A1SMN1; SMN2LMNAGALR2MITF | |
| SCHEMBL9721603 | 0.75 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2LMNAGALR2MITF | |
| SCHEMBL11591274 | 0.74 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2MITFHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481741-B2 | Preparation methods of 6 substituted amino-3 cyanoquinoline compounds and the intermediates thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2013-07-09 | — | — | US | disclosed |
| US-20110263860-A1 | PREPARATION METHODS OF 6-SUBSTITUTED AMINO-3-CYANOQUINOLINE COMPOUNDS AND THE INTERMEDIATES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263860-A1 | PREPARATION METHODS OF 6-SUBSTITUTED AMINO-3-CYANOQUINOLINE COMPOUNDS AND THE INTERMEDIATES THEREOF | QPCT, CBR3, KCNQ2 | ALDH1A1 772/4885SMN1; SMN2 4702/4885LMNA 582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.