Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | TPMT | P51580 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2536673 | 0.98 | KMT2A (0.53) | KMT2ACA12CA1CA2CA4 | |
| SCHEMBL27949094 | 0.87 | TSHR (0.48) | KMT2ATSHRHTR2AHTR2CHTR2B | |
| SCHEMBL10762377 | 0.86 | ALDH1A1 (0.57) | KMT2ATSHRHTR2AHTR2CHTR2B | |
| SCHEMBL2536664 | 0.86 | KMT2A (0.55) | KMT2ACA12CA1CA2CA4 | |
| SCHEMBL30628216 | 0.86 | ALDH1A1 (0.57) | KMT2ATSHRHTR2AHTR2CHTR2B | |
| SCHEMBL28288812 | 0.86 | CA12 (0.50) | KMT2ACA12CA1CA2CA4 | |
| SCHEMBL3545163 | 0.85 | KMT2A (0.58) | KMT2ACA12CA1CA2CA4 | |
| SCHEMBL17020098 | 0.84 | HTT (0.49) | KMT2ACA12CA1CA2CA4 | |
| SCHEMBL16605596 | 0.84 | PARP10 (0.56) | KMT2ATSHRHTR2AHTR2CHTR2B | |
| SCHEMBL2536671 | 0.84 | TSHR (0.47) | KMT2ATSHRHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11192886-B2 | S1P1 agonist and application thereof | MEDSHINE DISCOVERY INC. (CN) | 2021-12-07 | — | — | US | disclosed |
| CN-109956912-B | Carboxylic acid compound containing diphenyl oxadiazole, preparation method and medical application thereof | 中国医学科学院药物研究所 | 2021-10-22 | — | — | CN | disclosed |
| US-10385070-B2 | Chroman-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-08-20 | — | — | US | disclosed |
| US-10385070-B2 | Chroman-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-08-20 | — | — | US | disclosed |
| CN-105473554-B | Condensed piperidine amide as ion channel modulators | 沃泰克斯药物股份有限公司 | 2019-08-13 | — | — | CN | disclosed |
| CN-109956912-A | Carboxylic acid compound, preparation method and the medical usage of the oxadiazoles containing diphenyl | 中国医学科学院药物研究所 | 2019-07-02 | — | — | CN | disclosed |
| US-10233191-B2 | Fused piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-03-19 | — | — | US | disclosed |
| EP-2675812-B1 | CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2017-08-30 | — | — | EP | disclosed |
| EP-2675812-B1 | CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2017-08-30 | — | — | EP | disclosed |
| US-20170145011-A1 | Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMA (US) | 2017-05-25 | — | — | US | disclosed |
| US-20110230463-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | ASTELLAS PHARMA INC. (JP) | 2011-09-22 | — | — | US | disclosed |
| US-20100087495-A1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-04-08 | — | — | US | disclosed |
| US-20100087495-A1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-04-08 | — | — | US | disclosed |
| US-20100087495-A1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-04-08 | — | — | US | disclosed |
| CN-101619057-A | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARM INC | 2010-01-06 | — | — | CN | disclosed |
| CN-101522645-A | Phenyl derivatives and their use as immunomodulators | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-02 | — | — | CN | disclosed |
| CN-100509804-C | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARM INC (US) | 2009-07-08 | — | — | CN | disclosed |
| EP-2069318-A1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008035239-A1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-03-27 | — | — | WO | disclosed |
| CN-1675201-A | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARM INC (US) | 2005-09-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145011-A1 | Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels | KCNJ2, KCNJ5, KCNJ1 | KMT2A 2577/4885CA12 4097/4885CA1 1844/4885 |
| US-11192886-B2 | S1P1 agonist and application thereof | S1PR1, S1PR2, S1PR3 | KMT2A 3072/4885CA12 3842/4885CA1 3821/4885 |
| US-20110230463-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | S1PR1, S1PR2, CCR1 | KMT2A 2928/4885CA12 4227/4885CA1 3678/4885 |
| US-10233191-B2 | Fused piperidine amides as modulators of ion channels | TRPV1, TRPA1, KCNJ2 | KMT2A 1347/4885CA12 4567/4885CA1 1822/4885 |
| US-10385070-B2 | Chroman-spirocyclic piperidine amides as modulators of ion channels | KCNJ2, KCNJ1, KCNC1 | KMT2A 2130/4885CA12 4263/4885CA1 1622/4885 |
| US-20100087495-A1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | IL2, CD47, CD74 | KMT2A 2793/4885CA12 4671/4885CA1 4855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.