Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | APEX1 | P27695 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25432780 | 0.78 | ALDH1A1 (0.47) | MAPTRAB9ASMN1; SMN2RECQLKDM4E | |
| SCHEMBL15058294 | 0.74 | POLB (0.50) | SMN1; SMN2RECQLPOLBTDP1APEX1 | |
| SCHEMBL28057093 | 0.70 | RECQL (0.43) | SMN1; SMN2RECQLKDM4EPOLBTDP1 | |
| SCHEMBL15058993 | 0.69 | RECQL (0.43) | MAPTRAB9ASMN1; SMN2RECQLGAA | |
| SCHEMBL4414820 | 0.68 | MKNK1 (0.39) | MAPTRAB9ASMN1; SMN2RECQLGAA | |
| SCHEMBL3834300 | 0.67 | ALDH1A1 (0.40) | MAPTRAB9ASMN1; SMN2RECQLKDM4E | |
| SCHEMBL27630469 | 0.67 | RECQL (0.38) | MAPTRECQLPOLBTDP1APEX1 | |
| SCHEMBL3879873 | 0.66 | CSF1R (0.36) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3038302 | 0.65 | MAPT (0.70) | MAPTRAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL76912 | 0.65 | SMN1; SMN2 (0.52) | RAB9ASMN1; SMN2GAAKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023170025-A1 | AMIDO CYCLOPROPYL DERIVATIVES AS LPA RECEPTOR INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-09-14 | — | — | WO | disclosed |