Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.62 |
| ▸ | GRIA4 | P48058 | 13/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15609964 | 0.86 | GRIA1 (0.71) | GRIA1GRIA4NPY5R | |
| SCHEMBL13610004 | 0.84 | GRIA1 (0.75) | GRIA1GRIA4GRIA2GRIA3NPY5R | |
| SCHEMBL7039391 | 0.77 | GRIA1 (1.00) | GRIA1GRIA4NPY5R | |
| SCHEMBL7109326 | 0.77 | GRIA1 (1.00) | GRIA1GRIA4NPY5R | |
| SCHEMBL7042049 | 0.77 | GRIA1 (1.00) | GRIA1GRIA4NPY5R | |
| SCHEMBL8366386 | 0.77 | GRIA1 (0.65) | GRIA1GRIA4 | |
| SCHEMBL147252 | 0.77 | GRIA1 (0.65) | GRIA1GRIA4GRIA2GRIA3NPY5R | |
| SCHEMBL3161747 | 0.76 | GRIA1 (0.58) | GRIA1GRIA4 | |
| SCHEMBL147253 | 0.75 | GRIA1 (0.62) | GRIA1GRIA4NPY5R | |
| SCHEMBL18198023 | 0.75 | GRIA1 (0.62) | GRIA1GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4463457-B1 | PYRROLO[1,2-B]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | SUVEN LIFE SCIENCES LTD (IN) | 2026-02-04 | — | — | EP | disclosed |
| US-12275746-B2 | Pyrrolo[1,2-b]-2-pyridazinone compounds as 5-HT4 receptor agonists | SUVEN LIFE SCIENCES LIMITED (IN) | 2025-04-15 | — | — | US | disclosed |
| US-20250019386-A1 | PYRROLO[1,2-b]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | SUVEN LIFE SCIENCES LIMITED (IN) | 2025-01-16 | — | — | US | disclosed |
| EP-4463457-A1 | PYRROLO[1,2-/b]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | Suven Life Sciences Limited (IN) | 2024-11-20 | — | — | EP | disclosed |
| WO-2023135508-A1 | PYRROLO[1,2-b]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | SUVEN LIFE SCIENCES LIMITED (IN) | 2023-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12275746-B2 | Pyrrolo[1,2-b]-2-pyridazinone compounds as 5-HT4 receptor agonists | HTR4, HTR5A, HTR1B | GRIA1 369/4885GRIA4 173/4885GRIA2 366/4885 |
| US-20250019386-A1 | PYRROLO[1,2-b]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | HTR4, HTR5A, HTR1B | GRIA1 369/4885GRIA4 173/4885GRIA2 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.