Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FURIN | P09958 | 9/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | NRP1 | O14786 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 3/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | NPY4R | P50391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etelcalcetide SCHEMBL29647613 | 0.87 | SIRT5 (0.49) | SIRT5FURINSIRT2NRP1CHRM2 | |
| Etelcalcetide SCHEMBL30221949 | 0.86 | SIRT5 (0.48) | SIRT5FURINSIRT2NRP1CHRM2 | |
| Etelcalcetide SCHEMBL22578460 | 0.80 | SIRT5 (0.49) | SIRT5FURINSIRT2NRP1NPY1R | |
| Etelcalcetide SCHEMBL20869502 | 0.73 | SIRT5 (0.44) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| Etelcalcetide SCHEMBL21982605 | 0.73 | SIRT5 (0.44) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| Etelcalcetide SCHEMBL20869503 | 0.73 | SIRT5 (0.44) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| Etelcalcetide SCHEMBL22578458 | 0.73 | SIRT5 (0.43) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| Etelcalcetide SCHEMBL22578464 | 0.73 | SIRT5 (0.43) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| Hydrochloric Acid SCHEMBL28425407 | 0.73 | SIRT5 (0.43) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| SCHEMBL30080701 | 0.71 | CHRM2 (0.58) | SIRT5FURINSIRT2NRP1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230201313-A1 | METHODS OF TREATING LEFT VENTRICLE HYPERTROPHY | AMGEN INC. | 2023-06-29 | — | — | US | disclosed |