Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Etelcalcetide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.49 |
| ▸ | FURIN | P09958 | 9/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | NPY4R | P50391 | 1/20 | 0.42 |
| ▸ | NRP1 | O14786 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etelcalcetide SCHEMBL30221949 | 0.99 | SIRT5 (0.48) | SIRT5FURINSIRT2NPY1RCHRM2 | |
| Etelcalcetide SCHEMBL22578460 | 0.91 | SIRT5 (0.49) | SIRT5FURINSIRT2NPY1RNPY5R | |
| SCHEMBL25439421 | 0.87 | SIRT5 (0.40) | SIRT5FURINSIRT2NPY1RCHRM2 | |
| Etelcalcetide SCHEMBL20869502 | 0.84 | SIRT5 (0.44) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| Etelcalcetide SCHEMBL21982605 | 0.84 | SIRT5 (0.44) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| Etelcalcetide SCHEMBL20869503 | 0.84 | SIRT5 (0.44) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| Etelcalcetide SCHEMBL22578458 | 0.83 | SIRT5 (0.43) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| Etelcalcetide SCHEMBL22578464 | 0.83 | SIRT5 (0.43) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| Hydrochloric Acid SCHEMBL28425407 | 0.83 | SIRT5 (0.43) | SIRT5NPY1RNPY5RNPY2RNPY4R | |
| SCHEMBL30080701 | 0.81 | CHRM2 (0.58) | SIRT5FURINSIRT2NPY1RCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12162954-B2 | Method for preparing etelcalcetide hydrochloride | KRISAN BIOTECH CO., LTD. (TW) | 2024-12-10 | — | — | US | claimed |
| US-20230099078-A1 | METHOD FOR PREPARING AMG 416 (ETELCALCETIDE) | AMGEN INC. | 2023-03-30 | — | — | US | claimed |
| US-20230043220-A1 | METHOD FOR PREPARING ETELCALCETIDE HYDROCHLORIDE | KRISAN BIOTECH CO., LTD. (TW) | 2023-02-09 | — | — | US | claimed |
| US-11377474-B2 | Method for preparing AMG 416 (etelcalcetide) | AMGEN INC. (US) | 2022-07-05 | — | — | US | claimed |
| US-20260144935-A1 | DRIVE ASSEMBLY FOR A DRUG DELIVERY DEVICE AND RELATED METHODS | AMGEN INC. (US) | 2026-05-28 | — | — | US | disclosed |
| EP-4240450-B1 | DRUG DELIVERY DEVICE ASSEMBLY AND ACCESSORY FOR DRUG DELIVERY DEVICE | AMGEN INC (US) | 2026-05-20 | — | — | EP | disclosed |
| US-20260124394-A1 | DRUG DELIVERY DEVICES, COMPONENTS FOR USE WITHIN DRUG DELIVERY DEVICES, AND METHODS OF OPERATING DRUG DELIVERY DEVICES | AMGEN INC (US) | 2026-05-07 | — | — | US | disclosed |
| US-12618859-B2 | Methods and systems for automated syringe quality evaluation | AMGEN INC. (US) | 2026-05-05 | — | — | US | disclosed |
| US-12616795-B2 | Drug delivery device and methods of delivering a drug | AMGEN INC. (US) | 2026-05-05 | — | — | US | disclosed |
| US-12611507-B2 | Drug delivery device, subassembly for drug delivery device, syringe holder, and method of assembly | AMGEN INC. (US) | 2026-04-28 | — | — | US | disclosed |
| US-20260108674-A1 | Damper Overfill Chamber to Increase Functional Robustness Regarding Variance in Parts and Processes | AMGEN INC. (US) | 2026-04-23 | — | — | US | disclosed |
| US-12605512-B2 | Drug delivery device | AMGEN INC. (US) | 2026-04-21 | — | — | US | disclosed |
| US-20220355025-A1 | NEEDLE INSERTION MECHANISM FOR DRUG DELIVERY DEVICE | AMGEN INC (US) | 2022-11-10 | — | — | US | disclosed |
| US-20220340326-A1 | PACKAGES FOR PHARMACEUTICAL PRODUCTS AND METHODS OF ASSEMBLY | AMGEN INC. | 2022-10-27 | — | — | US | disclosed |
| US-20220313924-A1 | SYRINGE DE-CAPPER DEVICE | AMGEN INC. | 2022-10-06 | — | — | US | disclosed |
| US-20220288315-A1 | DRUG DELIVERY DEVICE HAVING REMOVABLE CAP | AMGEN INC. | 2022-09-15 | — | — | US | disclosed |
| US-20220288324-A1 | DRUG DELIVERY DEVICE | AMGEN INC. | 2022-09-15 | — | — | US | disclosed |
| US-20220288326-A1 | DRUG DELIVERY DEVICE, SUBASSEMBLY FOR DRUG DELIVERY DEVICE, SYRINGE HOLDER, AND METHOD OF ASSEMBLY | AMGEN INC. | 2022-09-15 | — | — | US | disclosed |
| US-20220281146-A1 | MANUFACTURING PROCESS FOR HOLLOW PLUNGER ROD | AMGEN INC. | 2022-09-08 | — | — | US | disclosed |
| US-20220265975-A1 | LIGHT-ACTIVATED ULTRASONIC DELIVERY AND MANIPULATION OF LIQUID MEDICATION FROM A DRUG RESERVOIR | AMGEN INC. | 2022-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12616795-B2 | Drug delivery device and methods of delivering a drug | ABCC1, USE1, CRH | SIRT5 3813/4885FURIN 799/4885SIRT2 2323/4885 |
| US-12605512-B2 | Drug delivery device | SLC47A2, SLC47A1, RPTOR | SIRT5 3266/4885FURIN 2602/4885SIRT2 639/4885 |
| US-20260108674-A1 | Damper Overfill Chamber to Increase Functional Robustness Regarding Variance in Parts and Processes | MYOC, TNF, ATP2A1 | SIRT5 4087/4885FURIN 616/4885SIRT2 4497/4885 |
| US-20260124394-A1 | DRUG DELIVERY DEVICES, COMPONENTS FOR USE WITHIN DRUG DELIVERY DEVICES, AND METHODS OF OPERATING DRUG DELIVERY DEVICES | PER2, CRY1, CRH | SIRT5 2911/4885FURIN 181/4885SIRT2 2644/4885 |
| US-12611507-B2 | Drug delivery device, subassembly for drug delivery device, syringe holder, and method of assembly | USE1, TRAM1, LNPK | SIRT5 3003/4885FURIN 941/4885SIRT2 1420/4885 |
| US-12162954-B2 | Method for preparing etelcalcetide hydrochloride | PTH1R, ECE2, PTMS | SIRT5 3121/4885FURIN 7/4885SIRT2 3220/4885 |
| US-12618859-B2 | Methods and systems for automated syringe quality evaluation | EIF2A, EIF3D, SRPRA | SIRT5 4191/4885FURIN 3182/4885SIRT2 3346/4885 |
| US-11377474-B2 | Method for preparing AMG 416 (etelcalcetide) | CYP24A1, PTH1R, MME | SIRT5 2589/4885FURIN 100/4885SIRT2 3867/4885 |
| US-20230043220-A1 | METHOD FOR PREPARING ETELCALCETIDE HYDROCHLORIDE | PTH1R, ECE2, PTMS | SIRT5 3121/4885FURIN 7/4885SIRT2 3220/4885 |
| US-20260144935-A1 | DRIVE ASSEMBLY FOR A DRUG DELIVERY DEVICE AND RELATED METHODS | CRH, PDE1C, DYNLL2 | SIRT5 4720/4885FURIN 2889/4885SIRT2 4511/4885 |
| US-20230099078-A1 | METHOD FOR PREPARING AMG 416 (ETELCALCETIDE) | CYP24A1, PTH1R, MME | SIRT5 2589/4885FURIN 100/4885SIRT2 3867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.