Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27398571 | 0.89 | NPC1 (0.39) | GABRA5NPC1PTGS2MAPTRAB9A | |
| SCHEMBL30889520 | 0.77 | MAPT (0.37) | NPC1MAPTRAB9ASMN1; SMN2DGAT1 | |
| SCHEMBL22112683 | 0.70 | THRB (0.38) | NPC1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL25258361 | 0.70 | F11 (0.39) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL31629099 | 0.70 | GRIN2B (0.38) | MAPTRAB9AALDH1A1MEN1MAPK1 | |
| SCHEMBL3076793 | 0.69 | NPC1 (0.42) | NPC1MAPTDGAT1 | |
| SCHEMBL30903072 | 0.69 | NPC1 (0.36) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL30867579 | 0.69 | DGAT1 (0.39) | GABRA5NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL25911833 | 0.69 | F2RL1 (0.36) | NPC1KDM5AKDM5BMAPTALDH1A1 | |
| SCHEMBL30903056 | 0.68 | NPC1 (0.35) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118613483-A | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2024-09-06 | — | — | CN | disclosed |
| WO-2023146809-A9 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | WO | disclosed |
| WO-2023146809-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-08-03 | — | — | WO | disclosed |