SCHEMBL25447366

SCHEMBL25447366

O=C(NCCc1ccc(F)cc1)c1cc(Cl)nnc1Sc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.52
CA4 P22748 2/20 0.52
GAA P10253 1/20 0.48
NPC1 O15118 4/20 0.48
RAB9A P51151 4/20 0.48
CNR1 P21554 1/20 0.46
CNR2 P34972 1/20 0.46
MAPT P10636 2/20 0.46
LMNA P02545 1/20 0.46
TP53 P04637 1/20 0.46
KMT2A Q03164 1/20 0.45
ALDH1A1 P00352 2/20 0.45
KDM4E B2RXH2 1/20 0.44
SLC6A5 Q9Y345 1/20 0.43
PLAAT3 P53816 1/20 0.43
PLAAT5 Q96KN8 1/20 0.43
PLAAT2 Q9NWW9 1/20 0.43
PLAAT4 Q9UL19 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25447454 0.92 CA2 (0.59) CA2CA4NPC1RAB9AMAPT
SCHEMBL25447207 0.92 TDP1 (0.53) CA2CA4GAANPC1RAB9A
SCHEMBL25447261 0.91 MAPT (0.56) CA2CA4NPC1RAB9AMAPT
SCHEMBL25447231 0.90 CA2 (0.50) CA2CA4NPC1RAB9ACNR1
SCHEMBL25446939 0.89 CA2 (0.52) CA2CA4GAANPC1RAB9A
SCHEMBL25446970 0.87 KMT2A (0.63) CA2CA4GAANPC1RAB9A
SCHEMBL25447001 0.86 NPC1 (0.52) CA2CA4GAANPC1RAB9A
SCHEMBL25447285 0.85 MAPT (0.50) CA2CA4GAANPC1RAB9A
SCHEMBL25447347 0.85 HIF1A (0.47) CA2CA4NPC1RAB9ACNR1
SCHEMBL25446940 0.85 MAPT (0.48) CA2CA4NPC1RAB9ACNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023078915-A1 BIS(HETERO)ARYL THIOETHER (THIO)AMIDES AS FUNGICIDAL COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 2023-05-11 WO disclosed