SCHEMBL25447231

SCHEMBL25447231

O=C(NCCc1cccc(F)c1)c1cc(Cl)nnc1Sc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA2 P00918 3/20 0.50
CA4 P22748 3/20 0.50
LMNA P02545 1/20 0.48
POLB P06746 1/20 0.48
THRB P10828 1/20 0.48
TP53 P04637 2/20 0.46
CNR1 P21554 1/20 0.45
ABCB1 P08183 1/20 0.44
ALDH1A1 P00352 1/20 0.44
NPC1 O15118 4/20 0.44
RAB9A P51151 4/20 0.44
TAAR1 Q96RJ0 1/20 0.43
HIF1A Q16665 1/20 0.42
ATM Q13315 1/20 0.41
NAMPT P43490 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25447154 0.93 CNR1 (0.52) CA2CA4LMNAPOLBTHRB
SCHEMBL25447454 0.90 CA2 (0.59) CA2CA4LMNAPOLBTP53
SCHEMBL25447366 0.90 CA2 (0.52) CA2CA4LMNATP53CNR1
SCHEMBL25447034 0.88 CA2 (0.50) CA2CA4LMNAPOLBTHRB
SCHEMBL25447283 0.87 CA2 (0.48) CA2CA4LMNATP53CNR1
SCHEMBL25447036 0.85 KMT2A (0.51) CA2CA4LMNATP53CNR1
SCHEMBL25447261 0.85 MAPT (0.56) CA2CA4LMNATP53NPC1
SCHEMBL25447001 0.84 NPC1 (0.52) CA2CA4POLBTP53ALDH1A1
SCHEMBL25447347 0.83 HIF1A (0.47) CA2CA4CNR1ALDH1A1NPC1
SCHEMBL25447260 0.83 ALDH1A1 (0.50) CA2CA4LMNATHRBTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023078915-A1 BIS(HETERO)ARYL THIOETHER (THIO)AMIDES AS FUNGICIDAL COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 2023-05-11 WO disclosed