SCHEMBL25447367

SCHEMBL25447367

Cc1ccc(CCNC(=O)c2nc(C)nnc2Sc2cccc(C(F)(F)F)c2)c(C)c1

nearest known ligand 0.39

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 17/20 0.39
ALDH1A1 P00352 1/20 0.39
POLB P06746 1/20 0.39
SIRT2 Q8IXJ6 1/20 0.38
GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25447368 0.90 PARP1 (0.39) ALDH1A1POLB
SCHEMBL25448234 0.85 SIRT2 (0.39) CCR2ALDH1A1POLBSIRT2GAA
SCHEMBL30401439 0.85 HPGD (0.41) ALDH1A1SIRT2
SCHEMBL25169910 0.85 HPGD (0.41) ALDH1A1SIRT2
SCHEMBL25447387 0.77 P2RX7 (0.42) CCR2POLB
SCHEMBL25447932 0.76 CA2 (0.39) ALDH1A1POLBGAA
SCHEMBL25447933 0.75 POLB (0.44) ALDH1A1POLBGAA
SCHEMBL25447233 0.75 ABCG2 (0.38) CCR2ALDH1A1
SCHEMBL25447930 0.74 SIRT2 (0.36) POLBSIRT2
SCHEMBL25448056 0.73 EGLN2 (0.34) ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023078915-A1 BIS(HETERO)ARYL THIOETHER (THIO)AMIDES AS FUNGICIDAL COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 2023-05-11 WO disclosed