SCHEMBL25447387

SCHEMBL25447387

Cc1ccc(CCNC(=O)c2cc(Cl)ncc2Sc2cccc(C(F)(F)F)c2)c(C)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 2/20 0.42
GPR52 Q9Y2T5 2/20 0.41
KCNQ3 O43525 2/20 0.39
KCNQ2 O43526 2/20 0.39
HSP90AA1 P07900 1/20 0.38
MAPT P10636 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
POLB P06746 1/20 0.38
CCR2 P41597 4/20 0.37
KCNE1 P15382 1/20 0.37
KCNQ1 P51787 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
ATM Q13315 1/20 0.36
CCR1 P32246 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
KLKB1 P03952 1/20 0.36
PPARG P37231 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25447003 0.90 P2RX7 (0.44) P2RX7POLBNPC1RAB9AATM
SCHEMBL25446999 0.88 POLB (0.46) P2RX7MAPTPOLBNPC1RAB9A
SCHEMBL25447414 0.85 P2RX7 (0.41) P2RX7MAPTMEN1KMT2A
SCHEMBL30865777 0.84 P2RX7 (0.43) P2RX7
SCHEMBL30251335 0.82 PPARG (0.44) P2RX7KCNQ3KCNQ2HSP90AA1MAPT
SCHEMBL25447233 0.81 ABCG2 (0.38) P2RX7GPR52KCNQ3KCNQ2MAPT
SCHEMBL25448028 0.79 POLB (0.40) KCNQ3KCNQ2MAPTPOLBNPC1
SCHEMBL25447985 0.77 POLB (0.47) MAPTPOLBRAB9A
SCHEMBL25447367 0.77 CCR2 (0.39) POLBCCR2
SCHEMBL25447953 0.77 CA2 (0.42) P2RX7KCNQ3KCNQ2POLBKCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023078915-A1 BIS(HETERO)ARYL THIOETHER (THIO)AMIDES AS FUNGICIDAL COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 2023-05-11 WO disclosed