Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 14/20 | 0.56 |
| ▸ | PRKAB1 | Q9Y478 | 14/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 11/20 | 0.56 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.48 |
| ▸ | TFDP2 | Q14188 | 1/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12241666 | 0.88 | PRKAG1 (0.72) | PRKAG1PRKAB1PRKAA1PRKAA2PRKAB2 | |
| SCHEMBL2545110 | 0.86 | PRKAG1 (0.49) | PRKAG1PRKAB1PRKAA1PRKAA2PRKAB2 | |
| SCHEMBL2545115 | 0.85 | PRKAG1 (0.47) | PRKAG1PRKAB1PRKAA1PRKAA2PRKAB2 | |
| SCHEMBL2544477 | 0.82 | PRKAG1 (0.55) | PRKAG1PRKAB1PRKAA1PRKAA2PRKAB2 | |
| SCHEMBL2547736 | 0.80 | PRKAG1 (0.69) | PRKAG1PRKAB1PRKAA1PRKAA2PRKAB2 | |
| SCHEMBL9909905 | 0.78 | PRKAG1 (0.60) | PRKAG1PRKAB1PRKAA1PRKAA2PRKAB2 | |
| SCHEMBL3481283 | 0.77 | PRKAG1 (0.79) | PRKAG1PRKAB1PRKAA1PRKAA2PRKAB2 | |
| SCHEMBL30408372 | 0.77 | PRKAG1 (0.79) | PRKAG1PRKAB1PRKAA1PRKAA2PRKAB2 | |
| SCHEMBL12241810 | 0.77 | PRKAG1 (0.61) | PRKAG1PRKAB1PRKAA1PRKAA2PRKAB2 | |
| SCHEMBL12241814 | 0.76 | PRKAG1 (0.62) | PRKAG1PRKAB1PRKAA1PRKAA2PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348857-B1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2016-02-24 | — | — | EP | disclosed |
| EP-2348857-B1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2016-02-24 | — | — | EP | disclosed |
| US-8410284-B2 | Cyclic benzimidazole derivatives useful as anti-diabetic agents | MERCK SHARP & DOHME CORP (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410284-B2 | Cyclic benzimidazole derivatives useful as anti-diabetic agents | MERCK SHARP & DOHME CORP (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410284-B2 | Cyclic benzimidazole derivatives useful as anti-diabetic agents | MERCK SHARP & DOHME CORP (US) | 2013-04-02 | — | — | US | disclosed |
| US-20110263533-A1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME CORP. | 2011-10-27 | — | — | US | disclosed |
| US-20110263533-A1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME CORP. | 2011-10-27 | — | — | US | disclosed |
| US-20110263533-A1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME CORP. | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263533-A1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | PRKAG2, PRKAG1, PRKAB2 | PRKAG1 2/4885PRKAB1 5/4885PRKAA1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.