Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 15/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 15/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2510619 | 0.74 | PIK3CD (0.57) | CYP11B1CYP11B2CYP19A1PIK3CDPIK3R1 | |
| SCHEMBL2551721 | 0.73 | CYP11B1 (0.44) | CYP11B1CYP11B2CYP19A1PIK3CDPIK3R1 | |
| SCHEMBL12196828 | 0.69 | PIK3CD (0.57) | CYP11B1CYP11B2CYP19A1PIK3CDPIK3R1 | |
| SCHEMBL12265568 | 0.67 | PIK3CD (0.49) | CYP11B1CYP11B2CYP19A1PIK3CDPIK3R1 | |
| SCHEMBL2553878 | 0.67 | PIK3CD (0.58) | CYP11B1CYP11B2CYP19A1PIK3CDPIK3R1 | |
| SCHEMBL2507030 | 0.67 | PIK3CD (0.58) | CYP11B1CYP11B2CYP19A1PIK3CDPIK3R1 | |
| SCHEMBL12263414 | 0.66 | PIK3CD (0.68) | CYP11B1CYP11B2CYP19A1PIK3CDPIK3R1 | |
| SCHEMBL15188267 | 0.66 | CYP11B2 (0.53) | CYP11B1CYP11B2CYP19A1PIK3CDPIK3R1 | |
| SCHEMBL2549015 | 0.66 | AKT1 (0.48) | CYP11B1CYP11B2PIK3CDPIK3R1PIK3CB | |
| SCHEMBL15261705 | 0.62 | ATM (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552908-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |