Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 7/20 | 0.48 |
| ▸ | AKT2 | P31751 | 6/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318629 | 0.78 | AKT1 (0.53) | AKT1AKT2PIK3CDPIK3R1PIK3CB | |
| SCHEMBL2715655 | 0.74 | PIK3CD (0.44) | PIK3CDSLC2A1TRPA1 | |
| SCHEMBL2548473 | 0.73 | PIK3CD (0.64) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL2504442 | 0.72 | PIK3CD (0.55) | AKT1AKT2PIK3CDPIK3R1PIK3CB | |
| SCHEMBL12196845 | 0.71 | PIK3CD (0.54) | AKT1AKT2PIK3CDPIK3R1PIK3CB | |
| SCHEMBL15730473 | 0.69 | AKT1 (0.56) | AKT1AKT2CYP11B1CYP11B2ALDH1A3 | |
| Hydrochloric Acid SCHEMBL18128834 | 0.68 | AKT1 (0.55) | AKT1AKT2CYP11B1CYP11B2ALDH1A3 | |
| SCHEMBL1320928 | 0.66 | MAPK14 (0.49) | AKT1AKT2 | |
| SCHEMBL30847319 | 0.66 | AKT1 (0.50) | AKT1AKT2CYP11B1CYP11B2ALDH1A3 | |
| SCHEMBL2545478 | 0.66 | CYP11B1 (0.43) | PIK3CDPIK3R1PIK3CBPIK3CGCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552908-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |