Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.45 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 4/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 4/20 | 0.39 |
| ▸ | CES1 | P23141 | 4/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23009850 | 0.98 | EPHX1 (0.48) | EPHX1SPHK2SPHK1CNR1FAAH | |
| SCHEMBL9281657 | 0.91 | CASP2 (0.48) | EPHX1SPHK2SPHK1FAAHCASP2 | |
| SCHEMBL11588184 | 0.88 | EPHX1 (0.50) | EPHX1SPHK2SPHK1FAAHCASP2 | |
| SCHEMBL905747 | 0.83 | EPHX1 (0.43) | EPHX1CNR1CASP2EPHX2 | |
| SCHEMBL23449135 | 0.83 | FAAH (0.52) | SPHK2SPHK1FAAHCES2CES1 | |
| SCHEMBL17887989 | 0.83 | SLC6A5 (0.45) | EPHX1SPHK2SPHK1DNM1 | |
| SCHEMBL16892758 | 0.82 | — | — | |
| SCHEMBL3022186 | 0.81 | CASP2 (0.41) | EPHX1SPHK2SPHK1FAAHCASP2 | |
| SCHEMBL3026606 | 0.80 | CASP2 (0.44) | EPHX1SPHK2SPHK1FAAHCASP2 | |
| SCHEMBL26751913 | 0.79 | CASP2 (0.57) | EPHX1SPHK2SPHK1FAAHCASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694853-B1 | PROCESS FOR THE PREPARATION OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6-DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CARBONITRILE | ARRAY BIOPHARMA INC (US) | 2023-05-17 | — | — | EP | disclosed |