Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Oxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Oxide SCHEMBL3993955 | 0.67 | — | — | |
| Nitric Oxide SCHEMBL7560 | 0.67 | — | — | |
| Nitric Oxide SCHEMBL306589 | 0.58 | — | — | |
| Nitric Oxide SCHEMBL2731176 | 0.58 | — | — | |
| Nitric Oxide SCHEMBL2888647 | 0.58 | — | — | |
| SCHEMBL25271841 | 0.58 | — | — | |
| SCHEMBL16617245 | 0.58 | — | — | |
| Charcoal, Activated SCHEMBL1535100 | 0.58 | — | — | |
| Nitric Oxide SCHEMBL5104249 | 0.58 | — | — | |
| SCHEMBL23039391 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117883449-A | ENPP1 inhibitors and their use for the treatment of cancer | 里兰斯坦福初级大学理事会 | 2024-04-16 | — | — | CN | disclosed |
| CN-111372587-B | ENPP1 inhibitors and their use for the treatment of cancer | 里兰斯坦福初级大学理事会 | 2024-01-09 | — | — | CN | disclosed |
| CN-106795177-B | BACE1 inhibitors | 豪夫迈·罗氏有限公司 | 2019-04-23 | — | — | CN | disclosed |
| CN-106795177-A | BACE1 inhibitors | 豪夫迈·罗氏有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-103282203-B | Barrier laminate and production method thereof | TOYO SEIKAN GROUP HOLDINGS, LTD. (JP) | 2016-01-06 | — | — | CN | disclosed |
| CN-102596569-B | Gas barrier laminate and method for producing same | TOYO SEIKAN KAISHA LTD | 2015-06-10 | — | — | CN | disclosed |
| EP-2816644-A1 | Battery | Novaled GmbH (DE) | 2014-12-24 | — | — | EP | disclosed |
| US-20130265757-A1 | LIGHT-EMITTING DEVICE | PANASONIC CORPORATION (JP) | 2013-10-10 | — | — | US | disclosed |
| CN-103282203-A | Gas barrier laminate and method for producing same | TOYO SEIKAN KAISHA LTD | 2013-09-04 | — | — | CN | disclosed |
| CN-102596569-A | Gas barrier laminate and method for producing same | TOYO SEIKAN KAISHA LTD | 2012-07-18 | — | — | CN | disclosed |
| EP-1054874-B1 | SUBSTITUTED AMINOPHENYL ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS | UPJOHN CO (US) | 2002-08-28 | — | — | EP | disclosed |
| US-20020091116-A1 | Show selectivity for factor Xa versus other proteases of coagulation or the fibrinolytic cascades | MILLENNIUM PHARMACEUTICALS, INC. | 2002-07-11 | — | — | US | disclosed |
| EP-1216231-A2 | INHIBITORS OF FACTOR Xa | Millennium Pharmaceuticals, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019798-A2 | INHIBITORS OF FACTOR Xa | COR THERAPEUTICS INC. (US) | 2001-03-22 | — | — | WO | disclosed |
| EP-1054874-A1 | SUBSTITUTED AMINOPHENYL ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS | PHARMACIA & UPJOHN COMPANY (US) | 2000-11-29 | — | — | EP | disclosed |
| US-6069141-A | BACTERICIDES | PHARMACIA & UPJOHN COMPANY (US) | 2000-05-30 | — | — | US | disclosed |
| US-6022977-A | Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0971906-A1 | LIPASE CATALYZED DYNAMIC RESOLUTION OF ISOXAZOLINE THIOESTERS TO ISOXAZOLINE CARBOXYLIC ACIDS | Du Pont Pharmaceuticals Company (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1999041244-A1 | SUBSTITUTED AMINOPHENYL ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS | PHARMACIA & UPJOHN COMPANY (US) | 1999-08-19 | — | — | WO | disclosed |
| WO-1998042687-A1 | LIPASE CATALYZED DYNAMIC RESOLUTION OF ISOXAZOLINE THIOESTERS TO ISOXAZOLINE CARBOXYLIC ACIDS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-10-01 | — | — | WO | disclosed |