Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
| ▸ | CCNH | P51946 | 1/20 | 0.30 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21455110 | 0.84 | MAPK8 (0.39) | MAPK8MAPK9MAPK10PDE3BPDE3A | |
| SCHEMBL29828263 | 0.78 | MAPK8 (0.36) | MAPK8MAPK9MAPK10PDE3BPDE3A | |
| SCHEMBL4129449 | 0.74 | DYRK1A (0.41) | MAPK8MAPK9MAPK10PDE3BPDE3A | |
| SCHEMBL29641025 | 0.73 | CA12 (0.36) | MAPK8MAPK9MAPK10PDE3BPDE3A | |
| SCHEMBL23264212 | 0.72 | NUDT1 (0.31) | — | |
| SCHEMBL3334033 | 0.72 | PDE3B (0.44) | MAPK8MAPK9MAPK10PDE3BPDE3A | |
| SCHEMBL19019072 | 0.71 | PDE3B (0.38) | MAPK8MAPK9MAPK10PDE3BPDE3A | |
| SCHEMBL16416249 | 0.69 | MAPK8 (0.48) | MAPK8MAPK9MAPK10PDE3BPDE3A | |
| SCHEMBL29837916 | 0.69 | HTR1A (0.44) | MAPK8MAPK9MAPK10PDE3BPDE3A | |
| SCHEMBL1983844 | 0.68 | ALDH1A1 (0.43) | MAPK8MAPK9MAPK10PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023083297-A1 | SMALL MOLECULE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-19 | — | — | WO | disclosed |