Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30374957 | 0.79 | ALDH1A1 (0.54) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25179894 | 0.79 | ALDH1A1 (0.54) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL28808758 | 0.78 | JAK2 (0.54) | ALDH1A1JAK2JAK1NOS1AXL | |
| SCHEMBL31735970 | 0.74 | ALDH1A1 (0.50) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25470822 | 0.74 | ALDH1A1 (0.44) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25472483 | 0.72 | AKR1B1 (0.42) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25180487 | 0.72 | PKM (0.50) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30375603 | 0.70 | PRMT5 (0.40) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25192750 | 0.70 | PRMT5 (0.40) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25183965 | 0.69 | NAMPT (0.40) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |