Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | JAK1 | P23458 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 4/20 | 0.53 |
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | METAP2 | P50579 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | DHPS | P49366 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1077138 | 0.85 | NOS1 (0.55) | JAK2JAK1NOS1AXLIDO1 | |
| SCHEMBL20789987 | 0.85 | NOS1 (0.55) | JAK2JAK1NOS1AXLIDO1 | |
| Hydrochloric Acid SCHEMBL28295355 | 0.84 | JAK2 (0.50) | JAK2JAK1NOS1AXLIDO1 | |
| SCHEMBL25468321 | 0.78 | ALDH1A1 (0.43) | JAK2JAK1NOS1AXLIDO1 | |
| SCHEMBL574814 | 0.75 | METAP2 (0.55) | JAK2JAK1NOS1AXLIDO1 | |
| SCHEMBL277054 | 0.74 | NOS1 (0.59) | JAK2JAK1NOS1AXLIDO1 | |
| SCHEMBL12601112 | 0.71 | NOS1 (0.61) | JAK2JAK1NOS1AXLIDO1 | |
| SCHEMBL29575075 | 0.71 | NOS1 (0.55) | JAK2JAK1NOS1AXLIDO1 | |
| SCHEMBL261171 | 0.71 | NOS1 (0.55) | JAK2JAK1NOS1AXLIDO1 | |
| SCHEMBL21894631 | 0.70 | JAK2 (1.00) | JAK2JAK1NOS1AXLIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103328471-A | Method of making azaindazole derivatives | TAKEDA PHARMACEUTICAL | 2013-09-25 | — | — | CN | disclosed |