Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | GRB2 | P62993 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL7323075 | 0.81 | HSP90AA1 (0.38) | HSP90AA1ADORA2AADORA1PDPK1TSHR | |
| SCHEMBL1489975 | 0.78 | HSP90AA1 (0.54) | HSP90AA1ADORA2AADORA1PDPK1LOXL2 | |
| SCHEMBL27754726 | 0.76 | HSP90AA1 (0.42) | HSP90AA1NOS1GRB2KMT2AKDM4E | |
| SCHEMBL6672732 | 0.74 | CHEK2 (0.43) | HSP90AA1ADORA2AADORA1PDPK1LOXL2 | |
| SCHEMBL2068779 | 0.73 | ALDH1A1 (0.56) | ADORA2AADORA1ALDH1A1HSD17B10RAB9A | |
| SCHEMBL23771960 | 0.73 | ADORA2A (0.44) | HSP90AA1ADORA2AADORA1PDPK1LOXL2 | |
| SCHEMBL16815742 | 0.73 | HSP90AA1 (0.41) | HSP90AA1ADORA2AADORA1PDPK1LOXL2 | |
| SCHEMBL23370176 | 0.73 | ADORA2A (0.44) | HSP90AA1ADORA2AADORA1PDPK1LOXL2 | |
| SCHEMBL2549740 | 0.73 | ADORA2A (0.49) | HSP90AA1ADORA2AADORA1PDPK1LOXL2 | |
| SCHEMBL5017807 | 0.73 | ADORA2A (0.49) | HSP90AA1ADORA2AADORA1PDPK1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102892761-A | 4 - aminopyrimidine derivatives and their as as adenosine a2a receptor antagonists | PALOBIOFARMA SL | 2013-01-23 | — | — | CN | claimed |
| EP-2552909-B1 | 4-AMINOPYRIMIDINE DERIVATIVES AND THEIR AS AS ADENOSINE A2A RECEPTOR ANTAGONISTS | PALOBIOFARMA SL (ES) | 2015-03-11 | — | — | EP | disclosed |
| US-8796284-B2 | 4-aminopyrimidine derivatives and their as as adenosine A2a receptor antagonists | PALOBIOFARMA, S.L. (ES) | 2014-08-05 | — | — | US | disclosed |
| US-20130053308-A1 | 4-AMINOPYRIMIDINE DERIVATIVES AND THEIR AS AS ADENOSINE A2a RECEPTOR ANTAGONISTS | PALOBIOFARMA, S.L. (ES) | 2013-02-28 | — | — | US | disclosed |
| EP-2552909-A1 | 4 - AMINOPYRIMIDINE DERIVATIVES AND THEIR AS AS ADENOSINE A2A RECEPTOR ANTAGONISTS | Palobiofarma, S.L. (ES) | 2013-02-06 | — | — | EP | disclosed |
| CN-102892761-A | 4 - aminopyrimidine derivatives and their as as adenosine a2a receptor antagonists | PALOBIOFARMA SL | 2013-01-23 | — | — | CN | disclosed |
| CN-101687863-B | Amino-thiazolyl-pyrimidine derivatives and their use to treat cancer | ASTRAZENECA AB | 2012-09-12 | — | — | CN | disclosed |
| WO-2011121418-A1 | 4 - AMINOPYRIMIDINE DERIVATIVES AND THEIR AS AS ADENOSINE A2A RECEPTOR ANTAGONISTS | PALOBIOFARMA, S.L. (ES) | 2011-10-06 | — | — | WO | disclosed |
| CN-101687863-A | Amino-thiazolyl-pyrimidine derivatives and their use to treat cancer | ASTRAZENECA AB | 2010-03-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053308-A1 | 4-AMINOPYRIMIDINE DERIVATIVES AND THEIR AS AS ADENOSINE A2a RECEPTOR ANTAGONISTS | ADORA2A, ADORA1, ADORA3 | HSP90AA1 3771/4885ADORA2A 1/4885ADORA1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.