Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2547716 | 0.89 | CES2 (0.47) | ALOX5CES2CES1KEAP1CHRM3 | |
| SCHEMBL2821064 | 0.81 | HPGD (0.45) | ALOX5CES2CES1KEAP1CHRM3 | |
| SCHEMBL442866 | 0.79 | CES2 (0.46) | ALOX5CES2CES1KEAP1CHRM3 | |
| SCHEMBL19187460 | 0.76 | ALOX5 (0.42) | ALOX5CES2CES1KEAP1CHRM3 | |
| SCHEMBL14033294 | 0.74 | ALOX5 (0.45) | ALOX5CES2CES1KEAP1HSD17B2 | |
| SCHEMBL10478379 | 0.74 | CES2 (0.41) | ALOX5CES2CES1KEAP1CHRM3 | |
| SCHEMBL72374 | 0.72 | CES2 (0.50) | ALOX5CES2CES1KEAP1CHRM3 | |
| SCHEMBL72373 | 0.72 | CES2 (0.50) | ALOX5CES2CES1KEAP1CHRM3 | |
| SCHEMBL28970770 | 0.72 | HCAR2 (0.45) | ALOX5CES2CES1KEAP1CHRM3 | |
| SCHEMBL11214693 | 0.71 | ALOX5 (0.42) | ALOX5CES2CES1KEAP1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552913-B1 | METHOD FOR SYNTHESIS OF TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2016-08-03 | — | — | EP | claimed |
| US-9242979-B2 | Methods for the synthesis of tiotropium bromide | BILGIC MAHMUT (TR) | 2016-01-26 | — | — | US | claimed |
| US-20150148540-A1 | METHODS FOR THE SYNTHESIS OF TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2015-05-28 | — | — | US | claimed |
| EP-2552913-A1 | METHOD FOR SYNTHESIS OF TIOTROPIUM BROMIDE | Bilgic, Mahmut (TR) | 2013-02-06 | — | — | EP | claimed |
| US-20130030182-A1 | METHODS FOR THE SYNTHESIS OF TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2013-01-31 | — | — | US | claimed |
| WO-2011123080-A1 | METHOD FOR SYNTHESIS OF TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2011-10-06 | — | — | WO | claimed |
| CN-104557905-B | A kind of preparation method of Tiotropium Bromide intermediate | 天津金耀集团有限公司 | 2018-02-23 | — | — | CN | disclosed |
| US-9440945-B2 | Methods for the synthesis of tiotropium bromide | BILGIC MAHMUT (TR) | 2016-09-13 | — | — | US | disclosed |
| US-20160221986-A1 | METHODS FOR THE SYNTHESIS OF TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2016-08-04 | — | — | US | disclosed |
| EP-2552913-B1 | METHOD FOR SYNTHESIS OF TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2016-08-03 | — | — | EP | disclosed |
| US-9242979-B2 | Methods for the synthesis of tiotropium bromide | BILGIC MAHMUT (TR) | 2016-01-26 | — | — | US | disclosed |
| US-20150148540-A1 | METHODS FOR THE SYNTHESIS OF TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2015-05-28 | — | — | US | disclosed |
| US-8957209-B2 | Methods for the synthesis of tiotropium bromide | BILGIC MAHMUT (TR) | 2015-02-17 | — | — | US | disclosed |
| EP-2552913-A1 | METHOD FOR SYNTHESIS OF TIOTROPIUM BROMIDE | Bilgic, Mahmut (TR) | 2013-02-06 | — | — | EP | disclosed |
| US-20130030182-A1 | METHODS FOR THE SYNTHESIS OF TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2013-01-31 | — | — | US | disclosed |
| WO-2011123080-A1 | METHOD FOR SYNTHESIS OF TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2011-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160221986-A1 | METHODS FOR THE SYNTHESIS OF TIOTROPIUM BROMIDE | CHRNA5, CHRNA9, CHRNA7 | ALOX5 724/4885CES2 2476/4885CES1 1653/4885 |
| US-20130030182-A1 | METHODS FOR THE SYNTHESIS OF TIOTROPIUM BROMIDE | CHRNA5, CHRNA9, CHRNA7 | ALOX5 724/4885CES2 2476/4885CES1 1653/4885 |
| US-20150148540-A1 | METHODS FOR THE SYNTHESIS OF TIOTROPIUM BROMIDE | CHRNA5, CHRNA9, CHRNA7 | ALOX5 724/4885CES2 2476/4885CES1 1653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.