Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.42 |
| ▸ | GSK3B | P49841 | 17/20 | 0.42 |
| ▸ | WNT1 | P04628 | 14/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548485 | 1.00 | DYRK1A (0.42) | DYRK1AGSK3BWNT1 | |
| SCHEMBL1742951 | 0.94 | GSK3B (0.42) | DYRK1AGSK3BWNT1 | |
| SCHEMBL1742953 | 0.90 | GSK3B (0.37) | DYRK1AGSK3BWNT1 | |
| SCHEMBL2541336 | 0.82 | FPR3 (0.34) | — | |
| SCHEMBL2541340 | 0.82 | FPR3 (0.34) | — | |
| SCHEMBL2550309 | 0.81 | AKT1 (0.40) | DYRK1AGSK3BWNT1 | |
| SCHEMBL2550295 | 0.81 | AKT1 (0.40) | DYRK1AGSK3BWNT1 | |
| SCHEMBL2548919 | 0.80 | PTPRB (0.34) | DYRK1AGSK3BWNT1 | |
| SCHEMBL2548917 | 0.80 | PTPRB (0.34) | DYRK1AGSK3BWNT1 | |
| SCHEMBL2547825 | 0.80 | PTPRB (0.37) | DYRK1AGSK3BWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2011-10-27 | — | — | US | disclosed |
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | TFEB, PCK2, JAK2 | DYRK1A 2916/4885GSK3B 145/4885WNT1 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.