Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2572968 | 0.87 | HCK (0.52) | HCKMAPK14MAPK12SMN1; SMN2RAB9A | |
| SCHEMBL2405629 | 0.86 | MAPK14 (0.48) | HCKMAPK14MAPK12SMN1; SMN2RAB9A | |
| SCHEMBL1978086 | 0.85 | MAPK14 (0.48) | HCKMAPK14MAPK12SMN1; SMN2RAB9A | |
| SCHEMBL1978082 | 0.85 | MAPK14 (0.48) | HCKMAPK14MAPK12SMN1; SMN2RAB9A | |
| SCHEMBL17017617 | 0.77 | ALDH1A1 (0.36) | HCKMAPK14AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2406235 | 0.76 | RAB9A (0.41) | HCKMAPK14MAPK12SMN1; SMN2RAB9A | |
| SCHEMBL15963830 | 0.76 | NPC1 (0.50) | AKR1C3AKR1C2AKR1C1SMN1; SMN2RAB9A | |
| SCHEMBL28705015 | 0.76 | SMN1; SMN2 (0.46) | HCKMAPK14MAPK12SMN1; SMN2RAB9A | |
| SCHEMBL12634044 | 0.75 | CYP11B1 (0.47) | HCKMAPK14MAPK12RAB9ANPC1 | |
| SCHEMBL2309475 | 0.75 | POLB (0.45) | HCKMAPK14MAPK12SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556067-A2 | PYRAZOLYL UREAS AS P38 MAP KINASE INHIBITORS | Respivert Limited (GB) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011124923-A2 | NOVEL COMPOUNDS | RESPIVERT LIMITED (GB) | 2011-10-13 | — | — | WO | disclosed |