Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28720004 | 1.00 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20338075 | 1.00 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20271528 | 1.00 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL50630 | 1.00 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL15225288 | 0.98 | ALDH1A1 (0.47) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL1752624 | 0.97 | ALDH1A1 (0.46) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL1860526 | 0.97 | ALDH1A1 (0.46) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL28764520 | 0.97 | ALDH1A1 (0.46) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL5049919 | 0.95 | ALDH1A1 (0.50) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL39073 | 0.94 | ALDH1A1 (0.43) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11589575-B2 | Injectable preserving medium for preserving cells from placental blood, from bone marrow and from peripheral blood | ETABLISSEMENT FRANCAIS DU SANG (FR) | 2023-02-28 | — | — | US | disclosed |
| US-20180184643-A1 | INJECTABLE PRESERVING MEDIUM FOR PRESERVING CELLS FROM PLACENTAL BLOOD, FROM BONE MARROW AND FROM PERIPHERAL BLOOD | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2018-07-05 | — | — | US | disclosed |
| CN-108135154-A | Injectable preservation Medium for preserving cells from placental blood, from bone marrow and from peripheral blood | 法国血液机构 | 2018-06-08 | — | — | CN | disclosed |
| US-8802363-B2 | Zeodration method for the preservation of blood platelets | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2014-08-12 | — | — | US | disclosed |
| US-20130078608-A1 | ZEODRATION METHOD FOR THE PRESERVATION OF BLOOD PLATELETS | ESTABLISSEMENT FRANCAIS DU SANG (FR) | 2013-03-28 | — | — | US | disclosed |
| EP-2555613-A1 | ZEODRATION METHOD FOR THE PRESERVATION OF BLOOD PLATELETS | INSERM - Institut National de la Santé et de la Recherche Médicale (FR) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011124280-A1 | ZEODRATION METHOD FOR THE PRESERVATION OF BLOOD PLATELETS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2011-10-13 | — | — | WO | disclosed |
| US-4338564-A | Hematology control composition and methods for its use | R & D SYSTEMS, INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4324686-A | BLOOD PLATELETS OF KNOWN COUNT RANGE, ELECTRONIC VOLUME, AND ELECTRONIC VOLUME SIZE DISTRIBUTION | R & D SYSTEMS, INC. (US) | 1982-04-13 | — | — | US | disclosed |