Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.30 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6754743 | 1.00 | ALDH1A1 (0.43) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL28080553 | 1.00 | ALDH1A1 (0.43) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL7102435 | 1.00 | ALDH1A1 (0.43) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20394112 | 1.00 | ALDH1A1 (0.43) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL28720004 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL2549366 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20338075 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20271528 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL50630 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL15225288 | 0.93 | ALDH1A1 (0.47) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3192 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4706691-A2 | ANAEROBIC BLOOD STORAGE AND PATHOGEN INACTIVATION METHOD | Hemanext Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-20260041772-A1 | Anaerobic Blood Storage and Pathogen Inactivation Method | HEMANEXT INC. (US) | 2026-02-12 | — | — | US | claimed |
| EP-4049677-B1 | ANAEROBIC BLOOD STORAGE AND PATHOGEN INACTIVATION METHOD | HEMANEXT INC (US) | 2025-12-10 | — | — | EP | claimed |
| WO-2025233323-A1 | DETECTION OF PATHOGENIC E. COLI STRAINS | Universität Bern (CH) | 2025-11-13 | — | — | WO | claimed |
| EP-4627345-A1 | MEASUREMENT OF REACTIVE OXYGEN SPECIES TO ASSESS RED BLOOD CELL QUALITY | University Of Maryland, Baltimore (US) | 2025-10-08 | — | — | EP | claimed |
| US-20250298040-A1 | MEASUREMENT OF REACTIVE OXYGEN SPECIES TO ASSESS RED BLOOD CELL QUALITY | UNIVERSITY OF MARYLAND, BALTIMORE | 2025-09-25 | — | — | US | claimed |
| US-12364760-B2 | Anaerobic blood storage and pathogen inactivation method | HEMANEXT INC. (US) | 2025-07-22 | — | — | US | claimed |
| US-20250189534-A1 | SAMPLE PREPARATION FOR GLYCOPROTEOMIC ANALYSIS THAT INCLUDES DIAGNOSIS OF DISEASE | VENN BIOSCIENCES CORP (US) | 2025-06-12 | — | — | US | claimed |
| EP-4483189-A2 | SAMPLE PREPARATION FOR GLYCOPROTEOMIC ANALYSIS THAT INCLUDES DIAGNOSIS OF DISEASE | Venn Biosciences Corporation (US) | 2025-01-01 | — | — | EP | claimed |
| US-20240374522-A1 | Formulations And Methods For Contemporaneous Stabilization Of Active Proteins During Spray Drying And Storage | VELICO MEDICAL, INC. (US) | 2024-11-14 | — | — | US | claimed |
| EP-0053046-B1 | STABILISATION OF FACTOR VIII ACTIVITY IN BLOOD PLASMA | Rock, Gail Ann (CA) | 1984-11-21 | — | — | EP | claimed |
| EP-0033582-B1 | METHOD OF OBTAINING FACTOR VIII | THE CANADIAN RED CROSS SOCIETY (CA) | 1984-04-11 | — | — | EP | claimed |
| US-4359463-A | Stabilization of Factor VIII activity in whole blood or blood plasma | CANADIAN RED CROSS SOCIETY, THE (CA) | 1982-11-16 | — | — | US | claimed |
| EP-0053046-A1 | Stabilisation of factor VIII activity in blood plasma | Rock, Gail Ann (CA) | 1982-06-02 | — | — | EP | claimed |
| US-4289691-A | FROM BLOOD PLASMA BY CRYOGENIC PRECIPITATION | THE CANADIAN RED CROSS SOCIETY (CA) | 1981-09-15 | — | — | US | claimed |
| EP-0033582-A2 | Method of obtaining factor VIII | THE CANADIAN RED CROSS SOCIETY (CA) | 1981-08-12 | — | — | EP | claimed |
| US-4216254-A | WITH ELECTRICAL DISCHARGE | UNION CARBIDE CORPORATION (US) | 1980-08-05 | — | — | US | claimed |
| US-4112070-A | Blood preservation system | RESEARCH CORPORATION (US) | 1978-09-05 | — | — | US | claimed |
| US-4073723-A | Anti-coagulating and filtering blood | COBE LABORATORIES, INC. | 1978-02-14 | — | — | US | claimed |
| US-4004975-A | HYDROXYETHYL STARCH, DIMETHYL SULFOXIDE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1977-01-25 | — | — | US | claimed |