Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL2549366 | 1.00 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL28720004 | 1.00 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20338075 | 1.00 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20271528 | 1.00 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL15225288 | 0.98 | ALDH1A1 (0.47) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL1752624 | 0.97 | ALDH1A1 (0.46) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL1860526 | 0.97 | ALDH1A1 (0.46) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL28764520 | 0.97 | ALDH1A1 (0.46) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL5049919 | 0.95 | ALDH1A1 (0.50) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL39073 | 0.94 | ALDH1A1 (0.43) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2578 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260079087-A1 | METHODS AND COMPOSITIONS FOR REVERSING PLATELET CLUMPING | TRUVIAN SCIENCES, INC. (US) | 2026-03-19 | — | — | US | claimed |
| EP-4680201-A1 | COMPOSITIONS AND USES THEREOF FOR STABILIZATION OF BLOOD SAMPLE COMPONENTS | Streck LLC (US) | 2026-01-21 | — | — | EP | claimed |
| US-12455218-B2 | Methods and compositions for reversing platelet clumping | TRUVIAN SCIENCES, INC. (US) | 2025-10-28 | — | — | US | claimed |
| EP-4618966-A2 | STABILIZED BLOOD DERIVED COMPOSITION USING ANTIFIBRINOLYTIC AGENTS | Turzi, Antoine (CH) | 2025-09-24 | — | — | EP | claimed |
| EP-3965885-B1 | METHODS AND COMPOSITIONS FOR REVERSING PLATELET CLUMPING | TRUVIAN SCIENCES INC (US) | 2025-03-26 | — | — | EP | claimed |
| WO-2024192232-A9 | COMPOSITIONS AND USES THEREOF FOR STABILIZATION OF BLOOD SAMPLE COMPONENTS | STRECK LLC (US) | 2025-02-06 | — | — | WO | claimed |
| US-20240350660-A1 | Compositions and Methods for Increasing Bioavailability Using Cyclodextrin Modification | HAUS BIOCEUTICALS INC (US) | 2024-10-24 | — | — | US | claimed |
| US-20240350659-A1 | COMPOSITIONS AND METHODS FOR BIMODAL ANTI-VIRAL COMBINATION THERAPY | HAUS BIOCEUTICALS INC (US) | 2024-10-24 | — | — | US | claimed |
| US-12102668-B2 | Process, tube and device for the preparation of wound healant composition | REGENLAB USA LLC (US) | 2024-10-01 | — | — | US | claimed |
| WO-2024192232-A1 | COMPOSITIONS AND USES THEREOF FOR STABILIZATION OF BLOOD SAMPLE COMPONENTS | STRECK LLC (US) | 2024-09-19 | — | — | WO | claimed |
| EP-1430920-A1 | Device and disposable line for extracorporeal blood treatment by citrate anticoagulation | Gambro Lundia AB (SE) | 2004-06-23 | — | — | EP | claimed |
| EP-1161143-B1 | COMPOSITIONS AND METHODS FOR PRESERVING PLATELETS | HUMAN BIOSYSTEMS (US) | 2004-05-26 | — | — | EP | claimed |
| US-20020009705-A1 | COMPOSITIONS, METHODS AND APPARATUSES FOR PRESERVING PLATELETS | HUMAN BIOSYSTEMS | 2002-01-24 | — | — | US | claimed |
| EP-1161143-A1 | COMPOSITIONS AND METHODS FOR PRESERVING PLATELETS | Hyperbaric Systems (US) | 2001-12-12 | — | — | EP | claimed |
| WO-2000053008-A1 | COMPOSITIONS AND METHODS FOR PRESERVING PLATELETS | HYPERBARIC SYSTEMS (US) | 2000-09-14 | — | — | WO | claimed |
| US-6106509-A | Closed circuit autologous sequestration reservoir system | LOUBSER PAUL G (US) | 2000-08-22 | — | — | US | claimed |
| US-5658271-A | Closed circuit autologous sequestration reservoir system | LOUBSER PAUL G (US) | 1997-08-19 | — | — | US | claimed |
| US-5629209-A | Method and apparatus for detecting viscosity changes in fluids | BRAUN BIOSYSTEMS, INC. | 1997-05-13 | — | — | US | claimed |
| US-5242792-A | Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1993-09-07 | — | — | US | claimed |
| US-4199022-A | Method of freezing living cells and tissues with improved subsequent survival | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF ENERGY (US) | 1980-04-22 | — | — | US | claimed |