SCHEMBL25494366

SCHEMBL25494366

CC(C)c1cn(-c2ccc(-c3ccc(C(C)(C)C)cc3)cc2)nn1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42
TRPV1 Q8NER1 3/20 0.41
S1PR1 P21453 5/20 0.40
KIF11 P52732 1/20 0.40
PTGS2 P35354 3/20 0.39
FLT1 P17948 1/20 0.38
KDR P35968 1/20 0.38
SCN5A Q14524 1/20 0.38
XDH P47989 1/20 0.36
NOTUM Q6P988 1/20 0.36
HSP90AA1 P07900 1/20 0.35
HSP90AB1 P08238 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25898936 0.83 ESRRA (0.48) S1PR1NOTUM
SCHEMBL22185933 0.81 NOTUM (0.55) CA12CA1CA2CA9TRPV1
SCHEMBL25494336 0.81 NOTUM (0.42) CA12CA1CA2CA9TRPV1
SCHEMBL25494321 0.81 NOTUM (0.39) CA12CA1CA2CA9TRPV1
SCHEMBL13160180 0.77 NOTUM (0.51) NOTUM
SCHEMBL13183607 0.77 NOTUM (0.53) CA12CA1CA2CA9PTGS2
SCHEMBL9729936 0.76 FLT3 (0.46) CA1CA2CA9PTGS2NOTUM
SCHEMBL13119830 0.75 P2RX7 (0.50) PTGS2NOTUM
SCHEMBL19589440 0.74 MAOA (0.50) FLT1KDRNOTUM
SCHEMBL24027315 0.74 CA12 (0.48) CA12CA1CA2CA9TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230158155-A1 Cell Surface Receptor Binding Compounds and Conjugates LYCIA THERAPEUTICS, INC. 2023-05-25 US disclosed
US-20230158155-A1 Cell Surface Receptor Binding Compounds and Conjugates LYCIA THERAPEUTICS, INC. 2023-05-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230158155-A1 Cell Surface Receptor Binding Compounds and Conjugates M6PR, ASGR1, IGF2R CA12 1621/4885CA1 3431/4885CA2 3060/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.