Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | PTPRB | P23467 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 3/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 2/20 | 0.30 |
| ▸ | CTSK | P43235 | 2/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1744901 | 0.91 | PTPRB (0.35) | PTPRBATMDYRK1AGSK3BPDPK1 | |
| SCHEMBL1743840 | 0.91 | AKT1 (0.40) | PTPRBATMDYRK1AGSK3BPDPK1 | |
| SCHEMBL12266678 | 0.88 | DYRK1A (0.33) | PTPRBATMDYRK1AGSK3BPDPK1 | |
| SCHEMBL12241747 | 0.86 | DYRK1A (0.34) | PTPRBDYRK1AGSK3BPDPK1WNT1 | |
| SCHEMBL13286102 | 0.86 | DYRK1A (0.34) | PTPRBDYRK1AGSK3BPDPK1WNT1 | |
| SCHEMBL1743901 | 0.86 | GSK3B (0.33) | PTPRBATMDYRK1AGSK3BPDPK1 | |
| SCHEMBL2550295 | 0.85 | AKT1 (0.40) | PTPRBATMDYRK1AGSK3BWNT1 | |
| SCHEMBL2550309 | 0.85 | AKT1 (0.40) | PTPRBATMDYRK1AGSK3BWNT1 | |
| SCHEMBL2547827 | 0.85 | PTPRB (0.37) | PTPRBATMDYRK1AGSK3BPDPK1 | |
| SCHEMBL2547825 | 0.85 | PTPRB (0.37) | PTPRBATMDYRK1AGSK3BPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | TFEB, PCK2, JAK2 | MLYCD 1019/4885PTPRB 879/4885ATM 332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.