Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ATP4A | P20648 | 1/20 | 0.38 |
| ▸ | ATP4B | P51164 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10676592 | 0.87 | STAT3 (0.45) | HTTSTAT3SMN1; SMN2LIPEMAPK1 | |
| SCHEMBL2557954 | 0.86 | HTT (0.42) | HTTSTAT3SMN1; SMN2LIPEMAPK1 | |
| SCHEMBL10369595 | 0.85 | PDGFRB (0.50) | HTTSTAT3SMN1; SMN2LMNAHPGD | |
| SCHEMBL18686908 | 0.80 | MAPT (0.47) | HTTSTAT3SMN1; SMN2LIPEFFAR4 | |
| SCHEMBL3934018 | 0.79 | TRPM8 (0.35) | ATP4AATP4B | |
| SCHEMBL8555177 | 0.79 | CDK1 (0.43) | LIPEMAPK1LMNAMAPTTDP1 | |
| SCHEMBL8554570 | 0.74 | MAPT (0.40) | SMN1; SMN2MAPK1LMNAALDH1A1HPGD | |
| SCHEMBL23582954 | 0.74 | TDP1 (0.58) | LIPEMAPK1LMNAALDH1A1MAPT | |
| SCHEMBL29847146 | 0.74 | TDP1 (0.58) | LIPEMAPK1LMNAALDH1A1MAPT | |
| SCHEMBL9366721 | 0.73 | NPC1 (0.47) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130150376-A1 | Novel Sultam Compounds | PFIZER INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-20130150376-A1 | Novel Sultam Compounds | PFIZER INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-20130150376-A1 | Novel Sultam Compounds | PFIZER INC. (US) | 2013-06-13 | — | — | US | disclosed |
| EP-2556076-A2 | NOVEL SULTAM COMPOUNDS | Pfizer Inc. (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011125006-A2 | NOVEL SULTAM COMPOUNDS | PFIZER INC. (US) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011125006-A2 | NOVEL SULTAM COMPOUNDS | PFIZER INC. (US) | 2011-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150376-A1 | Novel Sultam Compounds | SULT2A1, SULT1A1, SULT1E1 | HTT 1512/4885STAT3 2552/4885SMN1; SMN2 1078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.