Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | MET | P08581 | 3/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | TEK | Q02763 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19338219 | 0.80 | HSD17B10 (0.70) | KDRMETAURKBAURKATEK | |
| SCHEMBL29558136 | 0.80 | AXL (0.65) | KDRMETAURKBAURKATEK | |
| SCHEMBL1890635 | 0.80 | AXL (0.65) | KDRMETAURKBAURKATEK | |
| SCHEMBL258010 | 0.77 | BRAF (0.58) | POLBALDH1A1HPGDHDAC3BRAF | |
| SCHEMBL5664461 | 0.77 | BRAF (0.52) | HSD17B1MTNR1APOLBHSD17B10KDM4E | |
| SCHEMBL25501011 | 0.76 | POLB (0.56) | KDRMETAURKBAURKATEK | |
| SCHEMBL31557936 | 0.75 | ALDH1A1 (0.47) | MTNR1APOLBALDH1A1HPGDKMT2A | |
| SCHEMBL13915644 | 0.74 | ALDH1A1 (0.49) | HSD17B10KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL28834403 | 0.72 | ALDH1A1 (0.50) | HSD17B10KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL2746955 | 0.71 | KDR (0.82) | KDRMETAURKBAURKATEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081253-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | EXELIXIS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |