Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25501046 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL25501179 | 0.85 | KDM4E (0.41) | SMN1; SMN2MAPTALDH1A1RAB9ALMNA | |
| SCHEMBL25502295 | 0.85 | KDM4E (0.41) | SMN1; SMN2MAPTALDH1A1RAB9ALMNA | |
| SCHEMBL25501088 | 0.84 | ROCK2 (0.40) | SMN1; SMN2MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL25502298 | 0.83 | MEN1 (0.38) | SMN1; SMN2MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL25501160 | 0.83 | MEN1 (0.38) | SMN1; SMN2MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL25501064 | 0.81 | MAPT (0.37) | SMN1; SMN2MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL25502276 | 0.81 | MAPT (0.37) | SMN1; SMN2MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL22306344 | 0.81 | RAB9A (0.52) | SMN1; SMN2MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL25501203 | 0.81 | KMT2A (0.38) | SMN1; SMN2MAPTALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230149414-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230149414-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | SMN1; SMN2 40/4885MAPT 2074/4885ALDH1A1 2571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.