Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18713117 | 0.87 | KDM4E (0.40) | HRH3CHRM5ADRA2CACHEKDM4E | |
| SCHEMBL26143684 | 0.85 | CHRM5 (0.38) | HRH3CHRM5ADRA2CACHEKDM4E | |
| SCHEMBL23133620 | 0.83 | THRB (0.39) | HRH3CHRM5ADRA2CACHEALDH1A1 | |
| SCHEMBL24723848 | 0.82 | CHRM5 (0.53) | CHRM5ADRA2CACHEKDM4EALDH1A1 | |
| SCHEMBL12850091 | 0.80 | KDM4E (0.37) | HRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL22520700 | 0.80 | ACHE (0.50) | HRH3CHRM5ADRA2CACHEKDM4E | |
| SCHEMBL26480974 | 0.80 | ACHE (0.50) | HRH3CHRM5ADRA2CACHEKDM4E | |
| SCHEMBL24294565 | 0.80 | ACHE (0.40) | HRH3CHRM5ADRA2CACHEKDM4E | |
| SCHEMBL21158999 | 0.79 | KDM4E (0.36) | CHRM5ADRA2CACHEKDM4EALDH1A1 | |
| SCHEMBL25759060 | 0.79 | KDM4E (0.39) | HRH3CHRM5ADRA2CACHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648243-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2023-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11648243-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | HRH3 1000/4885CHRM5 2607/4885ADRA2C 3439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.