Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 2/20 | 0.49 |
| ▸ | TLR2 | O60603 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | PARP15 | Q460N3 | 6/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548484 | 0.86 | HPGD (0.50) | TLR4TLR2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL13836687 | 0.84 | SIGMAR1 (0.52) | TLR4TLR2SIGMAR1PARP15PARP10 | |
| SCHEMBL2552169 | 0.80 | SIGMAR1 (0.49) | TLR4TLR2SIGMAR1PARP15PARP10 | |
| SCHEMBL9112139 | 0.80 | SIGMAR1 (0.49) | TLR4TLR2SIGMAR1PARP15PARP10 | |
| SCHEMBL27038419 | 0.80 | SIGMAR1 (0.49) | TLR4TLR2SIGMAR1PARP15PARP10 | |
| SCHEMBL5765504 | 0.80 | SIGMAR1 (0.52) | TLR4TLR2SIGMAR1PARP15PARP10 | |
| SCHEMBL30140325 | 0.80 | SIGMAR1 (0.49) | TLR4TLR2SIGMAR1PARP15PARP10 | |
| SCHEMBL9109238 | 0.80 | MAPT (0.59) | ALDH1A1MAPTCYP3A4HPGDKDM4E | |
| SCHEMBL2545470 | 0.78 | SIGMAR1 (0.47) | TLR4TLR2SIGMAR1PARP15PARP10 | |
| SCHEMBL2558176 | 0.77 | PARP10 (0.49) | TLR4TLR2SIGMAR1PARP15PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563765-B1 | BICYCLIC COMPOUND DERIVATIVES AND THEIR USE AS ACC INHIBITORS. | TAKEDA PHARMACEUTICAL (JP) | 2015-05-27 | — | — | EP | disclosed |
| EP-2649062-B1 | BICYCLIC COMPOUNDS AS INHIBITORS OF ACETYL-COA CARBOXYLASE (ACC) | TAKEDA PHARMACEUTICAL (JP) | 2015-04-08 | — | — | EP | disclosed |
| CN-103025716-B | Bicyclic compound derivatives and their use as acc inhibitors | TAKEDA PHARMACEUTICAL | 2014-12-24 | — | — | CN | disclosed |
| CN-103347872-B | Bicyclic compound | TAKEDA PHARMACEUTICAL | 2014-12-24 | — | — | CN | disclosed |
| US-8729102-B2 | Bicyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-05-20 | — | — | US | disclosed |
| US-8703758-B2 | Bicyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-04-22 | — | — | US | disclosed |
| EP-2649062-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF ACETYL-COA CARBOXYLASE (ACC) | Takeda Pharmaceutical Company Limited (JP) | 2013-10-16 | — | — | EP | disclosed |
| CN-103347872-A | Bicyclic compound | TAKAEDA CHEMICAL IND LTD | 2013-10-09 | — | — | CN | disclosed |
| WO-2012074126-A9 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-06 | — | — | WO | disclosed |
| CN-103025716-A | Bicyclic compound derivatives and their use as acc inhibitors | TAKEDA PHARMACEUTICAL | 2013-04-03 | — | — | CN | disclosed |
| EP-2563765-A1 | BICYCLIC COMPOUND DERIVATIVES AND THEIR USE AS ACC INHIBITORS. | Takeda Pharmaceutical Company Limited (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-20120142714-A1 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-07 | — | — | US | disclosed |
| WO-2012074126-A1 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-07 | — | — | WO | disclosed |
| WO-2011136385-A1 | BICYCLIC COMPOUND DERIVATIVES AND THEIR USE AS ACC INHIBITORS. | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-03 | — | — | WO | disclosed |
| US-20110263562-A1 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263562-A1 | BICYCLIC COMPOUND | ACACA, CPT1B, ACACB | TLR4 3077/4885TLR2 3575/4885SIGMAR1 4827/4885 |
| US-20120142714-A1 | BICYCLIC COMPOUND | ACACA, ACACB, FABP4 | TLR4 2733/4885TLR2 3163/4885SIGMAR1 4230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.