Ascomycin

Ascomycin

SCHEMBL25512

CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 18/20 1.00
FKBP4 Q02790 2/20 1.00
MEN1 O00255 1/20 1.00
LMNA P02545 1/20 1.00
MAPT P10636 1/20 1.00
KMT2A Q03164 1/20 1.00
THRB P10828 1/20 1.00
ABCB11 O95342 2/20 0.90
ADORA3 P0DMS8 2/20 0.90
MLNR O43193 1/20 0.88
NR1I2 O75469 1/20 0.88
CYP3A4 P08684 1/20 0.88
ADRA2A P08913 1/20 0.88
ADRB3 P13945 1/20 0.88
CYP3A5 P20815 1/20 0.88
TBXA2R P21731 1/20 0.88
CYP3A7 P24462 1/20 0.88
HTR2A P28223 1/20 0.88
HTR2B P41595 1/20 0.88
MTOR P42345 1/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ascomycin SCHEMBL386169 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL14113233 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL386168 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL17721321 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL2390057 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL10262882 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL13492308 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL439467 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL22409504 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL452381 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7205 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-224286817-U Kit for detecting concentration of tacrolimus in whole blood SUZHOU YAOMING ZEKANG BIOTECHNOLOGY Co.,Ltd. (CN) 2026-05-26 CN claimed
US-20260097028-A1 Methods of Treating Myeloproliferative Neoplasms KARTOS THERAPEUTICS INC (US) 2026-04-09 US claimed
EP-4169923-B1 NOVEL PROLYL FK506 DERIVATIVES HAVING NEURITE GROWTH AND SYNAPSE FORMATION ACTIVITIES AND USES THEREOF MOLGENBIO CO LTD (KR) 2026-02-25 EP claimed
US-20260021051-A1 PHARMACEUTICAL FORMULATIONS VIVUS LLC (US) 2026-01-22 US claimed
US-20260021078-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF PULMONARY HYPERTENSION VIVUS LLC (US) 2026-01-22 US claimed
EP-4674894-A2 COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES Hemoteq AG (DE) 2026-01-07 EP claimed
EP-4274570-B1 ACTIVATORS OF THE BMP/SMAD AXIS FOR USE IN TREATING AND/OR PREVENTING MUSCLE ATROPHY UNIV DEGLI STUDI DI TORINO (IT) 2025-12-24 EP claimed
EP-4663688-A2 CROSSLINKERS Hemoteq AG (DE) 2025-12-17 EP claimed
US-20250326859-A1 ANTI-CANCER ANTIBODIES, COMBINATION THERAPIES, AND USES THEREOF PREC BIOLOGICS INC (US) 2025-10-23 US claimed
US-20250319110-A1 SURFACE CALR CHEMICAL INDUCERS ZON LEONARD (US) 2025-10-16 US claimed
EP-0711298-A1 ACTIVATED MACROLACTAMS HAVING IMMUNOMODULATORY ACTIVITIES ABBOTT LABORATORIES (US) 1996-05-15 EP claimed
WO-1996013249-A1 PHARMACEUTICAL COMPOSITIONS NOVARTIS AG (CH) 1996-05-09 WO claimed
WO-1996013273-A1 PHARMACEUTICAL COMPOSITIONS NOVARTIS AG (CH) 1996-05-09 WO claimed
WO-1995025812-A2 ASSAYS FOR IMMUNOSUPPRESSANTS SANDOZ LTD. (CH) 1995-09-28 WO claimed
WO-1995004061-A1 ACTIVATED MACROLACTAMS HAVING IMMUNOMODULATORY ACTIVITIES ABBOTT LABORATORIES (US) 1995-02-09 WO claimed
EP-0624093-A1 THE USE OF A COMPOUND FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF HIV INFECTION KARPAS, Abraham (GB) 1994-11-17 EP claimed
WO-1993025533-A1 METHODS AND REAGENTS FOR THE DETERMINATION OF IMMUNOSUPPRESSIVE AGENTS ABBOTT LABORATORIES (US) 1993-12-23 WO claimed
WO-1993014780-A1 THE USE OF A COMPOUND FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF HIV INFECTION KARPAS ABRAHAM (GB) 1993-08-05 WO claimed
EP-0485091-A1 Process for the production of analogues of immunomycin MERCK & CO. INC. (US) 1992-05-13 EP claimed
EP-0478235-A2 A directed biosynthesis for an immunomycin derivative MERCK & CO. INC. (US) 1992-04-01 EP claimed