Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 18/20 | 1.00 |
| ▸ | FKBP4 | Q02790 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.90 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.90 |
| ▸ | MLNR | O43193 | 1/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.88 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.88 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.88 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.88 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.88 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.88 |
| ▸ | HTR2A | P28223 | 1/20 | 0.88 |
| ▸ | HTR2B | P41595 | 1/20 | 0.88 |
| ▸ | MTOR | P42345 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ascomycin SCHEMBL386169 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4MEN1LMNAMAPT | |
| Ascomycin SCHEMBL14113233 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4MEN1LMNAMAPT | |
| Ascomycin SCHEMBL17721321 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4MEN1LMNAMAPT | |
| Ascomycin SCHEMBL2390057 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4MEN1LMNAMAPT | |
| Ascomycin SCHEMBL25512 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4MEN1LMNAMAPT | |
| Ascomycin SCHEMBL10262882 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4MEN1LMNAMAPT | |
| Ascomycin SCHEMBL13492308 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4MEN1LMNAMAPT | |
| Ascomycin SCHEMBL439467 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4MEN1LMNAMAPT | |
| Ascomycin SCHEMBL22409504 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4MEN1LMNAMAPT | |
| Ascomycin SCHEMBL452381 | 1.00 | FKBP1A (1.00) | FKBP1AFKBP4MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030229115-A1 | Tricyclo compounds, a process for their production and pharmaceutical composition containing the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-12-11 | — | — | US | claimed |
| US-20030170831-A1 | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2003-09-11 | — | — | US | claimed |
| US-6482845-B1 | Method for inhibiting interleukin-2 production using tricyclo compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-19 | — | — | US | claimed |
| EP-0753297-B1 | LOTION | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-09-25 | — | — | EP | claimed |
| US-6201005-B1 | ADMINISTERING TRICYCLO COMPOUNDS TO TREAT GRAFT-VERSUS-HOST DISEASE, AUTOIMMUNE DISEASES AND INFECTIONS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-13 | — | — | US | claimed |
| EP-0474126-B1 | Ointments containing tricyclic compound | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-03-19 | — | — | EP | claimed |
| EP-0753297-A1 | LOTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-15 | — | — | EP | claimed |
| EP-0669127-A1 | PROLONGED-ACTION PHARMACEUTICAL PREPARATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-08-30 | — | — | EP | claimed |
| EP-0658344-A1 | LIPOSOME PREPARATION CONTAINING TRICYCLIC COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-06-21 | — | — | EP | claimed |
| EP-0483842-B1 | Pharmaceutical compositions containing tricyclic compounds | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-12-14 | — | — | EP | claimed |
| EP-0484936-B1 | Suspensions containing tricyclic compounds | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-10-05 | — | — | EP | claimed |
| EP-0475994-B1 | MACROLIDES FOR THE TREATMENT OF REVERSIBLE OBSTRUCTIVE AIRWAYS DISEASES | FISONS PLC (GB) | 1994-09-14 | — | — | EP | claimed |
| EP-0484936-A1 | Suspensions containing tricyclic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-05-13 | — | — | EP | claimed |
| EP-0474126-A1 | Ointments containing tricyclic compound | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-11 | — | — | EP | claimed |
| EP-0184162-A2 | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-06-11 | — | — | EP | claimed |
| US-8101650-B2 | Method for treating a immunology-related disease | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-24 | — | — | US | disclosed |
| US-8067396-B2 | Amino alcohol compounds or phosphonic acid derivatives thereof | SANKYO COMPANY, LIMITED (JP) | 2011-11-29 | — | — | US | disclosed |
| EP-0463690-A1 | Antagonists of immunosuppressive macrolides | MERCK & CO. INC. (US) | 1992-01-02 | — | — | EP | disclosed |
| EP-0445975-A1 | New hydroxymacrolide derivatives having immunosuppressive activity | MERCK & CO. INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| EP-0184162-A2 | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229115-A1 | Tricyclo compounds, a process for their production and pharmaceutical composition containing the same | OTC, SLC11A2, TYMS | FKBP1A 1707/4885FKBP4 1955/4885MEN1 142/4885 |
| US-20030170831-A1 | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same | OTC, OAT, SLC11A2 | FKBP1A 2044/4885FKBP4 2175/4885MEN1 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.