Ascomycin

Ascomycin

SCHEMBL386169

CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 18/20 1.00
FKBP4 Q02790 2/20 1.00
MEN1 O00255 1/20 1.00
LMNA P02545 1/20 1.00
MAPT P10636 1/20 1.00
KMT2A Q03164 1/20 1.00
THRB P10828 1/20 1.00
ABCB11 O95342 2/20 0.90
ADORA3 P0DMS8 2/20 0.90
MLNR O43193 1/20 0.88
NR1I2 O75469 1/20 0.88
CYP3A4 P08684 1/20 0.88
ADRA2A P08913 1/20 0.88
ADRB3 P13945 1/20 0.88
CYP3A5 P20815 1/20 0.88
TBXA2R P21731 1/20 0.88
CYP3A7 P24462 1/20 0.88
HTR2A P28223 1/20 0.88
HTR2B P41595 1/20 0.88
MTOR P42345 1/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ascomycin SCHEMBL14113233 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL386168 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL17721321 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL2390057 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL25512 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL10262882 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL13492308 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL439467 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL22409504 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT
Ascomycin SCHEMBL452381 1.00 FKBP1A (1.00) FKBP1AFKBP4MEN1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0753297-B1 LOTION FUJISAWA PHARMACEUTICAL CO (JP) 2002-09-25 EP claimed
EP-0474126-B1 Ointments containing tricyclic compound FUJISAWA PHARMACEUTICAL CO (JP) 1997-03-19 EP claimed
EP-0753297-A1 LOTION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-01-15 EP claimed
EP-0483842-B1 Pharmaceutical compositions containing tricyclic compounds FUJISAWA PHARMACEUTICAL CO (JP) 1994-12-14 EP claimed
EP-0484936-B1 Suspensions containing tricyclic compounds FUJISAWA PHARMACEUTICAL CO (JP) 1994-10-05 EP claimed
EP-0475994-B1 MACROLIDES FOR THE TREATMENT OF REVERSIBLE OBSTRUCTIVE AIRWAYS DISEASES FISONS PLC (GB) 1994-09-14 EP claimed
EP-0484936-A1 Suspensions containing tricyclic compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-05-13 EP claimed
US-20230218589-A1 COMPOUND FOR PREVENTION OR TREATMENT OF A SKIN CANCER OR SKIN PRECANCER UNIQUEST PTY LTD (AU) 2023-07-13 US disclosed
EP-4161510-A1 COMPOUND FOR PREVENTION OR TREATMENT OF A SKIN CANCER OR SKIN PRECANCER UNIQUEST PTY LTD (AU) 2023-04-12 EP disclosed
US-8101650-B2 Method for treating a immunology-related disease DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-01-24 US disclosed
US-8067396-B2 Amino alcohol compounds or phosphonic acid derivatives thereof SANKYO COMPANY, LIMITED (JP) 2011-11-29 US disclosed
US-20090326038-A1 Method for treating a immunology-related disease SANKYO COMPANY, LIMITED (JP) 2009-12-31 US disclosed
US-7638551-B2 Amino alcohol compounds or phosphonic acid derivatives thereof SANKYO COMPANY, LIMITED (JP) 2009-12-29 US disclosed
EP-1471054-A1 AMINO ALCOHOL DERIVATIVE OR PHOSPHONIC ACID DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THESE Sankyo Company, Limited (JP) 2004-10-27 EP disclosed
EP-0851753-B1 AEROSOL COMPOSITIONS FUJISAWA PHARMACEUTICAL CO (JP) 2003-11-19 EP disclosed
EP-0753297-B1 LOTION FUJISAWA PHARMACEUTICAL CO (JP) 2002-09-25 EP disclosed
EP-0943327-A1 MEDICINAL COMPOSITION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-09-22 EP disclosed
EP-0474126-B1 Ointments containing tricyclic compound FUJISAWA PHARMACEUTICAL CO (JP) 1997-03-19 EP disclosed
EP-0753297-A1 LOTION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-01-15 EP disclosed
EP-0184162-B1 Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same FUJISAWA PHARMACEUTICAL CO (JP) 1994-04-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230218589-A1 COMPOUND FOR PREVENTION OR TREATMENT OF A SKIN CANCER OR SKIN PRECANCER FKBP1A, FKBP4, FKBP2 FKBP1A 1/4885FKBP4 2/4885MEN1 1014/4885
US-20090326038-A1 Method for treating a immunology-related disease C3AR1, HRH3, HRH2 FKBP1A 980/4885FKBP4 1313/4885MEN1 307/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.