Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 2/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30409053 | 1.00 | KDM4E (0.41) | KDM4EBRAFP2RX7MAPTALDH1A1 | |
| SCHEMBL1145007 | 0.83 | HCAR3 (0.41) | KDM4EBRAFMAPTALDH1A1HTT | |
| SCHEMBL30692607 | 0.83 | HCAR3 (0.41) | KDM4EBRAFMAPTALDH1A1HTT | |
| SCHEMBL16929785 | 0.80 | ATM (0.46) | KDM4EBRAFMAPTALDH1A1GAA | |
| SCHEMBL30409389 | 0.80 | ATM (0.46) | KDM4EBRAFMAPTALDH1A1GAA | |
| SCHEMBL17963354 | 0.77 | HPGDS (0.48) | ALDH1A1HTTCYP1A2CYP2C19RAB9A | |
| SCHEMBL12950687 | 0.77 | KMT2A (0.46) | BRAFP2RX7MAPTGAALMNA | |
| SCHEMBL12950682 | 0.76 | RXFP1 (0.47) | BRAFALDH1A1GAAHTTLMNA | |
| SCHEMBL4780688 | 0.76 | JAK2 (0.50) | KDM4EMAPTALDH1A1GAALMNA | |
| SCHEMBL12950676 | 0.74 | L3MBTL1 (0.46) | KDM4EBRAFMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078337-A1 | CDK8/19 DUAL INHIBITORS AND METHODS OF USE | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-11 | — | — | WO | disclosed |