SCHEMBL2551593

SCHEMBL2551593

O=CCOCCOCCC(=O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.41
EGLN1 Q9GZT9 4/20 0.41
ALKBH5 Q6P6C2 1/20 0.41
SUCNR1 Q9BXA5 1/20 0.41
HSD17B10 Q99714 2/20 0.35
PMP22 Q01453 2/20 0.35
BLM P54132 1/20 0.35
SLC15A2 Q16348 1/20 0.33
MAPK1 P28482 1/20 0.33
SLC13A3 Q8WWT9 1/20 0.33
OR51E2 Q9H255 1/20 0.33
TSHR P16473 4/20 0.32
ALDH1A1 P00352 3/20 0.32
TP53 P04637 2/20 0.32
HIF1A Q16665 2/20 0.32
SLC22A6 Q4U2R8 1/20 0.32
KDM5C P41229 3/20 0.31
PHF8 Q9UPP1 3/20 0.31
KDM2A Q9Y2K7 3/20 0.31
KDM6B O15054 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30411802 1.00 LMNA (0.41) LMNAEGLN1ALKBH5SUCNR1HSD17B10
SCHEMBL22445194 1.00 LMNA (0.41) LMNAEGLN1ALKBH5SUCNR1HSD17B10
SCHEMBL380859 0.95
SCHEMBL16134190 0.83 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1HSD17B10
SCHEMBL16134189 0.83 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1HSD17B10
SCHEMBL1766162 0.83 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1HSD17B10
SCHEMBL1536845 0.83 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1HSD17B10
SCHEMBL22771166 0.83 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1HSD17B10
SCHEMBL1766170 0.83 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1HSD17B10
SCHEMBL351356 0.83 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024006402-A1 SELECTIVE HISTONE DEACETYLASE 3 (HDAC3) DEGRADERS AND METHODS OF USE THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2024-01-04 WO disclosed
EP-4029510-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS Kodiak Sciences Inc. (US) 2022-07-20 EP disclosed
US-20220047709-A1 DEGRADERS OF WEE1 KINASE DANA-FARBER CANCER INSTITUTE, INC. (US) 2022-02-17 US disclosed
EP-3549963-B1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS KODIAK SCIENCES INC (US) 2022-01-12 EP disclosed
US-20210402015-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS KODIAK SCIENCES INC (US) 2021-12-30 US disclosed
US-10689366-B2 Compounds for MALT1 degredation CORNELL UNIVERSITY (US) 2020-06-23 US disclosed
US-20200171179-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS KODIAK SCIENCES INC. 2020-06-04 US disclosed
EP-3549963-A2 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS Kodiak Sciences Inc. (US) 2019-10-09 EP disclosed
EP-3535254-A1 COMPOUNDS FOR MALT1 DEGRADATION Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") (US) 2019-09-11 EP disclosed
US-20190263785-A1 COMPOUNDS FOR MALT1 DEGRADATION CORNELL UNIVERSITY (US) 2019-08-29 US disclosed
US-20170143841-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS KODIAK SCIENCES INC. 2017-05-25 US disclosed
US-9579390-B2 Compounds and methods for producing a conjugate REDWOOD BIOSCIENCE, INC. (US) 2017-02-28 US disclosed
CN-106432557-A HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS 科迪亚科学企业公司 2017-02-22 CN disclosed
US-20160038602-A1 Compounds and Methods for Producing a Conjugate REDWOOD BIOSCIENCE, INC. 2016-02-11 US disclosed
EP-2916835-A1 COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE Redwood Bioscience, Inc. (US) 2015-09-16 EP disclosed
WO-2014074218-A1 COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE REDWOOD BIOSCIENCE, INC. (US) 2014-05-15 WO disclosed
US-20140024776-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS OLIGASIS (US) 2014-01-23 US disclosed
CN-103492489-A High molecular weight zwitterionic polymers OLIGASIS 2014-01-01 CN disclosed
EP-2558538-A2 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS Oligasis (US) 2013-02-20 EP disclosed
WO-2011130694-A2 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS OLIGASIS (US) 2011-10-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10689366-B2 Compounds for MALT1 degredation CRBN, NFKB2, NFKB1 LMNA 2284/4885EGLN1 286/4885ALKBH5 1879/4885
US-20170143841-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS ACP1, PHOSPHO1, PARG LMNA 1773/4885EGLN1 1953/4885ALKBH5 600/4885
US-20140024776-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS ACP1, PHOSPHO1, PARG LMNA 1773/4885EGLN1 1953/4885ALKBH5 600/4885
US-20190263785-A1 COMPOUNDS FOR MALT1 DEGRADATION CRBN, NFKB2, NFKB1 LMNA 1830/4885EGLN1 329/4885ALKBH5 2496/4885
US-20220047709-A1 DEGRADERS OF WEE1 KINASE WEE1, WEE2, PPME1 LMNA 3059/4885EGLN1 2043/4885ALKBH5 2504/4885
US-20200171179-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS ACP1, PHOSPHO1, PARG LMNA 1773/4885EGLN1 1953/4885ALKBH5 600/4885
US-20160038602-A1 Compounds and Methods for Producing a Conjugate BCR, PAICS, MMAB LMNA 3372/4885EGLN1 3658/4885ALKBH5 1528/4885
US-20210402015-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS ACP1, PHOSPHO1, PARG LMNA 1773/4885EGLN1 1953/4885ALKBH5 600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.